Signaling to survive: linear ubiquitination in health and disease

被引：0

作者：

Gulustan Celik ^{[1
]}

Nadine Weinelt ^{[1
]}

Sjoerd J. L. van Wijk ^{[1
]}

机构：

[1] Goethe University Frankfurt,Institute for Experimental Pediatric Hematology and Oncology

[2] German Cancer Consortium (DKTK) Partner Site Frankfurt/Mainz and German Cancer Research Center (DKFZ),University Cancer Centre Frankfurt (UCT), University Hospital Frankfurt

[3] Goethe-University,undefined

来源：

BIOspektrum | 2025年 / 31卷 / 1期

关键词：

D O I：

10.1007/s12268-025-2402-3

中图分类号：

学科分类号：

摘要：

Post-translational modification with ubiquitin (Ub) controls protein stability, localization and function and occurs as single entity, or as poly-Ub chains, linked via lysine residues or the N-terminal methionine (M1 poly-Ub). Generated by the linear ubiquitin chain assembly complex (LUBAC) and counteracted by the deubiquitinating enzymes OTULIN and CYLD, M1 poly-Ub controls immune signaling, survival and cell death. Here, we discuss old and new functions of M1 poly-Ub in health and disease.

引用

页码：32 / 35

页数：3

共 50 条

[1] Role of Linear Ubiquitination in Health and Disease
Brazee, Patricia
Dada, Laura A.
Sznajder, Jacob I.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2016, 54 (06) : 761 - 768
[2] The Emerging Role of Linear Ubiquitination in Cell Signaling
Emmerich, Christoph H.
Schmukle, Anna C.
Walczak, Henning
SCIENCE SIGNALING, 2011, 4 (204)
[3] The role of ubiquitination in health and disease
Liao, Yan
Zhang, Wangzheqi
Liu, Yang
Zhu, Chenglong
Zou, Zui
MEDCOMM, 2024, 5 (10):
[4] Editorial: Regulation of Ubiquitination and Sumoylation Signaling in Disease
Lin, Zhenghong
Yan, Xiaohua
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
[5] Ubiquitination at the mitochondria in neuronal health and disease
Covill-Cooke, Christian
Howden, Jack H.
Birsa, Nicol
Kittler, Josef T.
NEUROCHEMISTRY INTERNATIONAL, 2018, 117 : 55 - 64
[6] LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling
Iwai, Kazuhiro
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 2021, 97 (03): : 120 - 133
[7] Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death
Iwai, Kazuhiro
FEBS JOURNAL, 2021, 288 (04) : 1060 - 1069
[8] Linear Ubiquitination
不详
DEUTSCHE LEBENSMITTEL-RUNDSCHAU, 2017, 113 (11) : 517 - 517
[9] Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer's disease and amyotrophic lateral sclerosis
Sato, Yusuke
Terawaki, Seigo
Oikawa, Daisuke
Shimizu, Kouhei
Okina, Yoshinori
Ito, Hidefumi
Tokunaga, Fuminori
FRONTIERS IN MOLECULAR BIOSCIENCES, 2023, 10
[10] Ubiquitination in Rho Signaling
Ding, Feng
Yin, Zhenyu
Wang, Hong-Rui
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2011, 11 (23) : 2879 - 2887

← 1 2 3 4 5 →