Identification and Synthesis of a New L-Carnitine Impurity

被引：0
作者：
Wang, X. [1 ]
Yan, S. [1 ]
Qiu, X. [2 ]
Hou, J. [2 ]
Chen, Z. [2 ]
机构：
[1] Changzhou Univ, Sch Pharm, Changzhou 213164, Jiangsu, Peoples R China
[2] Jiangsu Bioscene Pharmaceut Co Ltd, Changzhou 213125, Jiangsu, Peoples R China
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2024年 / 94卷 / 12期
关键词：
L-carnitine; L-carnitine impurities; 3-ethoxy-4-trimethylammonium; 2-butenoate; asymmetric synthesis; EFFICIENT SYNTHESIS; DEHYDROGENASE; PURIFICATION;
D O I：
10.1134/S1070363224120351
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AbstractL-Carnitine is an endogenous substance essential for energy metabolism in mammals and a drug for the treatment of cardiovascular and neurological diseases. In this study, we reported and characterized a new impurity of L-carnitine (3-ethoxy-4-trimethylammonium 2-butenoate). The compound was synthesized from ethyl 4-chloroacetoacetate by a three-step reaction. It can be used as the impurity reference for the quality study and control of L-carnitine.
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页码：3431 / 3435
页数：5
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