Post-translational modifications of immune checkpoints: unlocking new potentials in cancer immunotherapy

被引：0
|
作者：
Hu, Qiongjie [1 ,3 ]
Shi, Yueli [1 ,2 ]
Wang, Huang [4 ]
Bing, Liuwen [3 ]
Xu, Zhiyong [1 ,2 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 4, Dept Resp & Crit Care Med, Yiwu 322000, Zhejiang, Peoples R China
[2] Zhejiang Key Lab Precis Diag & Treatment Lung Canc, Yiwu 322000, Peoples R China
[3] Zhejiang Chinese Med Univ, Affiliated Hosp 3, Hangzhou 310013, Peoples R China
[4] Nanjing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Nanjing, Peoples R China
来源：
EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2025年 / 14卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cancer immunotherapy; Immune checkpoint blockade; Post-translational modifications; Ubiquitination; Phosphorylation; ANTIBODY-BASED PROTACS; CELL LUNG-CANCER; SIRP-ALPHA; TUMOR MICROENVIRONMENT; PD-L1; EXPRESSION; BREAST-CANCER; T-CELLS; COINHIBITORY PATHWAYS; REGULATES ANTITUMOR; ACQUIRED-RESISTANCE;
D O I：
10.1186/s40164-025-00627-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immunotherapy targeting immune checkpoints has gained traction across various cancer types in clinical settings due to its notable advantages. Despite this, the overall response rates among patients remain modest, alongside issues of drug resistance and adverse effects. Hence, there is a pressing need to enhance immune checkpoint blockade (ICB) therapies. Post-translational modifications (PTMs) are crucial for protein functionality. Recent research emphasizes their pivotal role in immune checkpoint regulation, directly impacting the expression and function of these key proteins. This review delves into the influence of significant PTMs-ubiquitination, phosphorylation, and glycosylation-on immune checkpoint signaling. By targeting these modifications, novel immunotherapeutic strategies have emerged, paving the way for advancements in optimizing immune checkpoint blockade therapies in the future.
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页数：28
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