共 34 条
mPEG-PCL modified Caffeic acid eye drops for endotoxin-induced uveitis treatment
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作者:

Wu, Yiping
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机构:
Shandong First Med Univ, Eye Hosp, Jinan, Shandong, Peoples R China Shandong First Med Univ, Eye Hosp, Jinan, Shandong, Peoples R China

Wang, Lixu
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机构:
Wenzhou Med Univ, Eye Hosp, State Key Lab Ophthalmol Optometry & Vis Sci, Wenzhou 325000, Zhejiang, Peoples R China Shandong First Med Univ, Eye Hosp, Jinan, Shandong, Peoples R China

Hu, Chengda
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机构:
Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou, Zhejiang, Peoples R China
Wenzhou Med Univ, Yuying ChildrenS Hosp, Wenzhou, Zhejiang, Peoples R China Shandong First Med Univ, Eye Hosp, Jinan, Shandong, Peoples R China

Tian, Ruikang
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Wenzhou Med Univ, Eye Hosp, State Key Lab Ophthalmol Optometry & Vis Sci, Wenzhou 325000, Zhejiang, Peoples R China Shandong First Med Univ, Eye Hosp, Jinan, Shandong, Peoples R China
机构:
[1] Shandong First Med Univ, Eye Hosp, Jinan, Shandong, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou, Zhejiang, Peoples R China
[3] Wenzhou Med Univ, Yuying ChildrenS Hosp, Wenzhou, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Eye Hosp, State Key Lab Ophthalmol Optometry & Vis Sci, Wenzhou 325000, Zhejiang, Peoples R China
关键词:
Anti-inflammatory;
Endotoxin-induced uveitis;
Caffeic acid;
Eye drops;
Nanoparticle;
DRUG-DELIVERY;
COPOLYMER MICELLES;
ORAL DELIVERY;
D O I:
10.1038/s41598-025-94296-4
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The modulation of inflammatory mediators has emerged as a critical therapeutic strategy in uveitis management. Current nonsteroidal anti-inflammatory therapies face limitations due to systemic side effects. Caffeic acid (CA), a natural polyphenol with anti-inflammatory properties, holds therapeutic potential but suffers from poor solubility and ocular irritation. This study aimed to develop mPEG-PCL-modified CA-loaded nanoparticles (NanoCA) as a non-invasive eye drop formulation to enhance CA's solubility, bioavailability, and efficacy in treating endotoxin-induced uveitis (EIU). NanoCA was synthesized via the thin-film hydration method, characterized for size, zeta potential, drug loading, and release profile. Cytotoxicity was assessed in human corneal epithelial and RAW264.7 cells. Ocular tolerance was tested via slit-lamp and histopathological examinations. In vivo efficacy was evaluated in an EIU rat model using clinical scoring, histopathology, and immunofluorescence. NanoCA formed uniform nanospheres (42.40 +/- 0.22 nm, -0.97 mV) with high encapsulation efficiency (99.17%). It exhibited sustained release over 12 h and reduced cytotoxicity compared to free CA. In EIU rats, NanoCA significantly suppressed inflammation, downregulated CD68 expression, and preserved aqueous barrier integrity. Histopathology confirmed minimal inflammatory infiltrates in NanoCA-treated eyes. The formulation demonstrated excellent ocular biocompatibility without corneal damage. NanoCA eye drops offer a safe, non-invasive therapeutic strategy for EIU, combining enhanced anti-inflammatory efficacy with high ocular tolerance. This nanoformulation presents a promising alternative to conventional CA delivery methods.
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Wenzhou Med Univ, Eye Hosp, Natl Engn Res Ctr Ophthalmol & Optometry, Wenzhou 325027, Peoples R China Wenzhou Med Univ, Eye Hosp, Natl Engn Res Ctr Ophthalmol & Optometry, Wenzhou 325027, Peoples R China

Ni, Yuanao
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Qu, Jia
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Wenzhou Med Univ, Eye Hosp, Natl Engn Res Ctr Ophthalmol & Optometry, Wenzhou 325027, Peoples R China Wenzhou Med Univ, Eye Hosp, Natl Engn Res Ctr Ophthalmol & Optometry, Wenzhou 325027, Peoples R China

Li, Xingyi
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Jiang, Jun
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