A prognostic index for advanced-stage extranodal natural killer/T-cell lymphoma: A multicenter study

被引：0

作者：

Fang, Xiaojie ^{[1
,2
]}

Zhou, Fenglan ^{[3
]}

Ye, Sheng ^{[4
]}

Zhang, Hongyu ^{[5
]}

Guo, Hongqiang ^{[6
]}

Chen, Xinggui ^{[7
]}

Liang, Chaoyong ^{[8
]}

Pu, Xingxiang ^{[9
]}

Cao, Yabing ^{[10
]}

Ren, Quanguang ^{[11
]}

Li, Xiaoqian ^{[12
]}

Zhai, Linzhu ^{[13
]}

Huang, He ^{[1
,2
]}

Hong, Huangming ^{[3
]}

机构：

[1] Sun Yat Sen Univ, Dept Med Oncol, Collaborat Innovat Ctr Canc Med, Canc Ctr, Guangzhou, Peoples R China

[2] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Canc Ctr, Guangzhou, Peoples R China

[3] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Affiliated Canc Hosp, Dept Med Oncol,Sichuan Canc Ctr, 55,Sect 4,South Renmin Rd, Chengdu 610042, Peoples R China

[4] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Med Oncol, Guangzhou, Peoples R China

[5] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Med Oncol, Zhuhai, Peoples R China

[6] He Nan Canc Hosp, Dept Med Oncol, Zhengzhou, Peoples R China

[7] Guangdong Med Univ, Affiliated Hosp, Dept Med Oncol, Zhanjiang, Peoples R China

[8] Guangxi Canc Hosp, Dept Med Oncol, Nanning, Peoples R China

[9] Hunan Canc Hosp, Dept Med Oncol, Changsha, Peoples R China

[10] Kiang Wu Hosp, Dept Med Oncol, Macau, Peoples R China

[11] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Med Oncol, Wuhan, Peoples R China

[12] Shandong Canc Hosp, Dept Med Oncol, Jinan, Peoples R China

[13] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Med Oncol, Guangzhou, Peoples R China

来源：

ANNALS OF HEMATOLOGY | 2025年 / 104卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Advanced-stage; Extranodal natural killer/T-cell lymphoma; Prognostic model; Risk stratification; NASAL-TYPE; NEOPLASMS; MODEL;

D O I：

10.1007/s00277-024-06160-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Advanced-stage extranodal natural killer/T-cell lymphoma (ENKTL) is a highly heterogeneous disease with very poor prognosis. All commonly utilized prognostic models incorporated both early-stage and advanced-stage patients in the modeling process. This study aim to design a prognostic model specifically for advanced-stage ENKTL, providing risk stratification in affected patients. We analyzed 291 patients with stage III/IV ENKTL receiving asparaginase-based chemotherapy from 8 institutions to develop a new prognostic model and validate it in an independent cohort consisted of 221 patients from 4 additional hospitals. The prognostic model included three independent variables based on a multivariate analysis for overall survival (OS): age, bone marrow invasiveness and visceral organ involvement. We identified three different risk groups: group 1, no adverse factors; group 2, one factor; and group 3, two or three factors, which were associated with 5-year OS rates of 66.0%, 32.3%, and 20.0%, respectively (P < 0.001). The prognostic index of natural killer lymphoma (PINK) and nomogram-revised risk index (NRI) were unsatisfactory for stratifying these patients. These results were validated and confirmed in an independent cohort. This newly proposed model can be used to guide risk-adapted treatment for advanced stage ENKTL.

引用

页码：445 / 455

页数：11

共 36 条

[1] The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms [J].

Alaggio, Rita ;

Amador, Catalina ;

Anagnostopoulos, Ioannis ;

Attygalle, Ayoma D. ;

Araujo, Iguaracyra Barreto de Oliveira ;

Berti, Emilio ;

Bhagat, Govind ;

Borges, Anita Maria ;

Boyer, Daniel ;

Calaminici, Mariarita ;

Chadburn, Amy ;

Chan, John K. C. ;

Cheuk, Wah ;

Chng, Wee-Joo ;

Choi, John K. ;

Chuang, Shih-Sung ;

Coupland, Sarah E. ;

Czader, Magdalena ;

Dave, Sandeep S. ;

de Jong, Daphne ;

Du, Ming-Qing ;

Elenitoba-Johnson, Kojo S. ;

Ferry, Judith ;

Geyer, Julia ;

Gratzinger, Dita ;

Guitart, Joan ;

Gujral, Sumeet ;

Harris, Marian ;

Harrison, Christine J. ;

Hartmann, Sylvia ;

Hochhaus, Andreas ;

Jansen, Patty M. ;

Karube, Kennosuke ;

Kempf, Werner ;

Khoury, Joseph ;

Kimura, Hiroshi ;

Klapper, Wolfram ;

Kovach, Alexandra E. ;

Kumar, Shaji ;

Lazar, Alexander J. ;

Lazzi, Stefano ;

Leoncini, Lorenzo ;

Leung, Nelson ;

Leventaki, Vasiliki ;

Li, Xiao-Qiu ;

Lim, Megan S. ;

Liu, Wei-Ping ;

Louissaint, Abner, Jr. ;

Marcogliese, Andrea ;

Medeiros, L. Jeffrey .

LEUKEMIA, 2022, 36 (07) :1720-1748

[2] Management of NK/T-Cell Lymphoma, Nasal Type [J].

Allen, Pamela B. ;

Lechowicz, Mary Jo .

JOURNAL OF ONCOLOGY PRACTICE, 2019, 15 (10) :513-+

[3] Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project [J].

Au, Wing-yan ;

Weisenburger, Dennis D. ;

Intragumtornchai, Tanin ;

Nakamura, Shigeo ;

Kim, Won-Seog ;

Sng, Ivy ;

Vose, Julie ;

Armitage, James O. ;

Liang, Raymond .

BLOOD, 2009, 113 (17) :3931-3937

[4] Validation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making [J].

Chen, Si-Ye ;

Yang, Yong ;

Qi, Shu-Nan ;

Wang, Ying ;

Hu, Chen ;

He, Xia ;

Zhang, Li-Ling ;

Wu, Gang ;

Qu, Bao-Lin ;

Qian, Li-Ting ;

Hou, Xiao-Rong ;

Zhang, Fu-Quan ;

Qiao, Xue-Ying ;

Wang, Hua ;

Li, Gao-Feng ;

Zhang, Yu-Jing ;

Zhu, Yuan ;

Cao, Jian-Zhong ;

Lan, Sheng-Min ;

Wu, Jun-Xin ;

Wu, Tao ;

Zhu, Su-Yu ;

Shi, Mei ;

Xu, Li-Ming ;

Yuan, Zhi-Yong ;

Yahalom, Joachim ;

Tsang, Richard ;

Song, Yu-Qin ;

Zhu, Jun ;

Su, Hang ;

Li, Ye-Xiong .

LEUKEMIA, 2021, 35 (01) :130-142

[5] Revised response criteria for malignant lymphoma [J].

Cheson, Bruce D. ;

Pfistner, Beate ;

Juweid, Malik E. ;

Gascoyne, Randy D. ;

Specht, Lena ;

Horning, Sandra J. ;

Coiffier, Bertrand ;

Fisher, Richard I. ;

Hagenbeek, Anton ;

Zucca, Emanuele ;

Rosen, Steven T. ;

Stroobants, Sigrid ;

Lister, T. Andrew ;

Hoppe, Richard T. ;

Dreyling, Martin ;

Tobinai, Kensei ;

Vose, Julie M. ;

Connors, Joseph M. ;

Federico, Massimo ;

Diehl, Volker .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (05) :579-586

[6] Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study [J].

Gao, Yan ;

He, Haixia ;

Li, Xueping ;

Zhang, Liling ;

Xu, Wei ;

Feng, Ru ;

Li, Wenyu ;

Xiao, Yin ;

Liu, Xinxiu ;

Chen, Yu ;

Wang, Xiaoxiao ;

Bai, Bing ;

Wu, Huijing ;

Cai, Qingqing ;

Li, Zhiming ;

Li, Jibin ;

Lin, Suxia ;

He, Yanxia ;

Ping, Liqin ;

Huang, Cheng ;

Mao, Jiaying ;

Chen, Xiujin ;

Zhao, Baitian ;

Huang, Huiqiang .

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 9 (01)

[7] A prognostic index for nasal-type early-stage extranodal natural killer/T-cell lymphoma: A multicenter study [J].

Hong, Huangming ;

Huang, He ;

Fang, Xiaojie ;

Wang, Zhao ;

Ye, Sheng ;

Zhang, Hongyu ;

Huang, Ying ;

Guo, Hongqiang ;

Chen, Xinggui ;

Liang, Chaoyong ;

Pu, Xingxiang ;

Cao, Yabing ;

Lin, Suxia ;

Li, Xueying ;

Ren, Quanguang ;

Liu, Qing ;

Lin, Tongyu .

AMERICAN JOURNAL OF HEMATOLOGY, 2019, 94 (05) :E122-E124

[8] Surgical resection followed by chemotherapy may be an effective treatment strategy for primary gastrointestinal natural killer/T-cell lymphoma: a single center experience [J].

Hong, Huangming ;

Liang, Chaoyong ;

Huang, He ;

Guo, Chengcheng ;

Tian, Ying ;

Liu, Tingzhi ;

Zhang, Mengping ;

Li, Xueying ;

Wang, Zhao ;

Fang, Xiaojie ;

Lin, Jiatian ;

Lin, Tongyu .

LEUKEMIA & LYMPHOMA, 2014, 55 (11) :2649-2651

[9] A novel prognostic nomogram based on imaging and molecular parameters for newly diagnosed extranodal natural killer/T-cell lymphoma patients [J].

Huang, Dezhi ;

Li, Fu ;

Lin, Shijia ;

Xia, Jing ;

Liu, Bangdong ;

Li, Xinlei ;

Ma, Naya ;

Duan, Yishuo ;

Zeng, Yunjing ;

Zhou, Sha ;

Tang, Shuhan ;

Huang, Wenqiu ;

Rao, Lingyi ;

Gao, Li ;

Li, Qiong ;

Zhang, Xi ;

Rao, Jun .

HAEMATOLOGICA, 2025, 110 (01) :200-205

[10] Clinical features and survival of extranodal natural killer/T cell lymphoma with and without hemophagocytic syndrome [J].

Jia, Jing ;

Song, Yuqin ;

Lin, Ningjing ;

Liu, Weiping ;

Ping, Lingyan ;

Zheng, Wen ;

Wang, Xiaopei ;

Xie, Yan ;

Tu, Meifeng ;

Zhang, Chen ;

Ying, Zhitao ;

Deng, Lijuan ;

Ding, Ning ;

Zhu, Jun .

ANNALS OF HEMATOLOGY, 2016, 95 (12) :2023-2031

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