Dietary and circulating omega-6 fatty acids and their impact on cardiovascular disease, cancer risk, and mortality: a global meta-analysis of 150 cohorts and meta-regression

被引：0

作者：

Sadeghi, Reza ^{[1
,2
,3
]}

Norouzzadeh, Mostafa ^{[1
,2
,3
]}

Hasanrashedi, Minoo ^{[1
,2
,3
]}

Jamshidi, Sanaz ^{[4
]}

Ahmadirad, Hamid ^{[5
,6
]}

Alemrajabi, Mahdi ^{[7
]}

Vafa, Mohammadreza ^{[1
,2
]}

Teymoori, Farshad ^{[1
,2
]}

机构：

[1] Iran Univ Med Sci, Nutr Sci Res Ctr, Tehran, Iran

[2] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran 1449614535, Iran

[3] Iran Univ Med Sci, Student Res Comm, Tehran, Iran

[4] Shiraz Univ Med Sci, Imam Ali Hosp, Kazerun, Iran

[5] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Nutr Sci Dept, Kermanshah, Iran

[6] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran

[7] Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2025年 / 23卷 / 01期

关键词：

Fatty acids; Linoleic acid; Neoplasms; Mortality; Cardiovascular diseases; Meta-analysis; CORONARY-HEART-DISEASE; LINOLEIC-ACID; OVARIAN-CANCER; ASSOCIATION; INFLAMMATION; BIOMARKERS; NUTRITION; MEN;

D O I：

10.1186/s12967-025-06336-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

BackgroundDespite the significant increase in omega-6 fatty acid consumption, evidence regarding their health impacts remains inconsistent. This study performs an umbrella review and updated meta-analysis to evaluate the association between dietary and circulating omega-6 levels and the risks of cardiovascular diseases (CVDs), cancer, and mortality.MethodsA systematic search was conducted in PubMed, Scopus, and Web of Science until January 2024 to identify eligible meta-analyses of prospective observational studies. The Cochrane risk of bias and GRADE tools were used to assess the risk of bias and certainty of the evidence, respectively.ResultsAnalysis of 150 publications revealed that higher dietary intake and circulating levels of omega-6 were associated with lower risks of CVDs, cancer incidence, and all-cause mortality in the general population, particularly for coronary heart disease and stroke. While omega-6 intake was linked to lower risks of lung and prostate cancers, it was associated with higher risks of ovarian and endometrial cancers. Subgroup analyses revealed that these protective associations were more pronounced in cohort studies and absent in populations with pre-existing health conditions.ConclusionsHigher dietary intake and circulating levels of omega-6 fatty acids were associated with lower risks of CVDs, cancers, and all-cause mortality. However, the associations vary by cancer type and are less evident in individuals with pre-existing health conditions. These findings highlight the potential benefits of omega-6 fatty acids for public health while underscoring the need for further research to address specific risks and underlying mechanisms.Trial registrationRegistration number (PROSPERO): CRD42024522842

引用

页数：14