Multi-target approach to Alzheimer's disease prevention and treatment: antioxidant, anti-inflammatory, and amyloid- modulating mechanisms

被引：0
作者：
Abbas, Kashif [1 ]
Mustafa, Mohd [2 ]
Alam, Mudassir [1 ]
Habib, Safia [2 ]
Ahmad, Waleem [3 ]
Adnan, Mohd [4 ]
Hassan, Md. Imtaiyaz [5 ]
Usmani, Nazura [1 ]
机构：
[1] Aligarh Muslim Univ, Fac Life Sci, Dept Zool, Aligarh 202002, India
[2] Aligarh Muslim Univ, JN Med Coll, Fac Med, Dept Biochem, Aligarh 202002, UP, India
[3] Aligarh Muslim Univ, JN Med Coll, Fac Med, Dept Med, Aligarh, India
[4] Univ Hail, Coll Sci, Dept Biol, Hail, Saudi Arabia
[5] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi, India
来源：
NEUROGENETICS | 2025年 / 26卷 / 01期
关键词：
Neuroinflammation; Antioxidants; Polyphenols; Alzheimer's; Dementia; Tau hyperphosphorylation; PRECURSOR PROTEIN APP; A-BETA OLIGOMERS; APOLIPOPROTEIN-E; INSULIN-RESISTANCE; OXIDATIVE STRESS; MOUSE MODEL; TRANSCRIPTION FACTORS; THERAPEUTIC TARGET; MEMORY IMPAIRMENT; TAU-PROTEIN;
D O I：
10.1007/s10048-025-00821-y
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Alzheimer's disease (AD) is characterized by amyloid-beta (A beta) plaque accumulation, neurofibrillary tangles, neuroinflammation, and progressive cognitive decline, posing a significant global health challenge. Growing evidence suggests that dietary polyphenols may reduce the risk and progression of AD through multifaceted neuroprotective mechanisms. Polyphenols regulate amyloid proteostasis by inhibiting beta/gamma-secretase activity, preventing A beta aggregation, and enhancing clearance pathways. Their strong antioxidant properties neutralize reactive oxygen species, chelate redox-active metals, and activate cytoprotective enzymes via Nrf2 signaling. This review examines the potential therapeutic targets, signaling pathways, and molecular mechanisms by which dietary polyphenols exert neuroprotective effects in AD, focusing on their roles in modulating amyloid proteostasis, oxidative stress, neuroinflammation, and cerebrovascular health. Polyphenols mitigate neuroinflammation by suppressing NF-kappa B signaling and upregulating brain-derived neurotrophic factor, supporting neuroplasticity and neurogenesis. They also enhance cerebrovascular health by improving cerebral blood flow, maintaining blood-brain barrier integrity, and modulating angiogenesis. This review examines the molecular and cellular pathways through which polyphenols exert neuroprotective effects, focusing on their antioxidant, anti-inflammatory, and amyloid-modulating roles. We also discuss their influence on key AD pathologies, including A beta deposition, tau hyperphosphorylation, oxidative stress, and neuroinflammation. Insights from clinical and preclinical studies highlight the potential of polyphenols in preventing or slowing AD progression. Future research should explore personalized dietary strategies that integrate genetic and lifestyle factors to optimize the neuroprotective effects of polyphenols.
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页数：20
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