Dynamic changes in the real-time glomerular filtration rate and kidney injury markers in different acute kidney injury models

被引：6

作者：

Xin, Yu ^{[1
,4
,5
]}

Liu, Yanqi ^{[1
,4
,5
]}

Liu, Linqiong ^{[1
,3
,4
,5
]}

Wang, Xinran ^{[1
,4
,5
]}

Wang, Dawei ^{[1
,2
,4
,5
]}

Song, Yuchen ^{[1
,4
,5
]}

Shen, Lifeng ^{[1
,4
,5
]}

Liu, Yuxi ^{[1
,3
,4
,5
]}

Liu, Yuhan ^{[1
,4
,5
]}

Peng, Yahui ^{[1
,4
,5
]}

Wang, Xibo ^{[1
,4
,5
]}

Zhou, Yang ^{[1
,4
,5
]}

Li, Hongxu ^{[1
,4
,5
]}

Zhou, Yuxin ^{[1
,4
,5
]}

Huang, Pengfei ^{[1
,4
,5
]}

Yuan, Mengyao ^{[1
,4
,5
]}

Xiao, Yu ^{[1
,4
,5
]}

Yu, Kaijiang ^{[1
,4
,5
]}

Wang, Changsong ^{[1
,4
,5
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Harbin 150007, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Canc Hosp, Dept Crit Care Med, 150 Haping Rd, Harbin 150081, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 4, Dept Crit Care Med, Harbin 150001, Heilongjiang, Peoples R China

[4] Harbin Med Univ, Affiliated Hosp 1, Cent Lab, Harbin, Heilongjiang, Peoples R China

[5] Heilongjiang Prov Key Lab Crit Care Med, Harbin, Heilongjiang, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2024年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Acute kidney injury; Real time glomerular filtration rate; Sepsis; Ischemia reperfusion; Cisplatin; Folic acid; Aristolochic acid; Vancomycin; Piperacillin tazobactam; Nephrotoxicity; TRANSCUTANEOUS MEASUREMENT; FITC-SINISTRIN; RENAL-FUNCTION;

D O I：

10.1186/s12967-024-05667-w

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In this study, we dynamically monitored the glomerular filtration rate and other assessment of renal function and markers of injury in various mice models of acute kidney injury. Male C57BL/6 mice were utilized to establish acute kidney injury models of sepsis, ischemia reperfusion, cisplatin, folic acid, aristolochic acid and antibiotic. In addition to the real time glomerular filtration rate, renal LCN-2 and HAVCR-1 mRNA expression levels, and serum creatinine, urea nitrogen and cystatin c levels were also used to evaluate renal function. In addition, the protein levels of LCN-2 and HAVCR-1 in renal, serum and urine were measured. Our results demonstrated that the changes in biomarkers always lagged the real time glomerular filtration rate during the progression and recovery of renal injury. Cystatin-c can reflect renal injury earlier than other markers, but it remains higher in the recovery stage. Perhaps the glomerular filtration rate does not reflect the greater injury caused by vancomycin plus piperacillin.

引用

页数：9

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