Beyond the skin: endocrine, psychological and nutritional aspects in women with hidradenitis suppurativa

Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory skin disorder that primarily affects body folds and the genital area, with a higher prevalence in women across Europe. The pathogenesis of HS involves a complex interplay of intrinsic and extrinsic factors, including genetics, immunity, hormones, and environmental influences. HS is frequently associated with a variety of comorbidities, such as metabolic, endocrine, and gastrointestinal conditions, as well as mental health disorders. Although the symptoms of HS are generally similar in both men and women, female patients may experience exacerbations of HS due to hormonal fluctuations during menstruation, pregnancy, breastfeeding, and menopause. These hormonal changes require special consideration by clinicians when managing HS in women. Due to its chronic nature and frequent flare-ups, HS significantly impacts patients' quality of life, affecting social interactions, emotional well-being, and psychological health. Women with HS may also experience sexual dysfunction, which is further exacerbated by emotional burdens such as shame, loss of femininity, and diminished intimacy. This review highlights key aspects of HS, extending beyond its skin manifestations to address endocrine, psychological, and nutritional aspects in the female population. It also underscores the importance of multidisciplinary collaboration in providing comprehensive care for women with this debilitating condition. Given the limited and largely off-label treatment options, a holistic approach is essential to ensure an appropriate management.