Dyslipidemia induced inflammation mediated the association between obesity and Osteoarthritis: a population-based study

被引：1
作者：
Yan, Laijun [1 ]
Ge, Haiya [1 ]
Xu, Qinguang [1 ]
Jiang, Ding [1 ]
Shen, Anping [1 ]
Yang, Muyun [1 ]
Zheng, Yuxin [1 ]
Cao, Yuelong [1 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Traumatol Orthoped, Shuguang Hosp Affiliated, Shis Ctr Orthoped & Traumatol,Shanghai Acad Trad, 528,Zhangheng Rd,Pudong New Area, Shanghai 201203, Peoples R China
来源：
BMC PUBLIC HEALTH | 2024年 / 24卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Obesity; Osteoarthritis; Lipid; Inflammation; Mediation; CHOLESTEROL; BIOMARKERS; MARKERS; PAIN;
D O I：
10.1186/s12889-024-20616-4
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Background This study aims to evaluate the mediation effect of dyslipidemia induced inflammation on the causal associations between obesity and Osteoarthritis (OA). Methods This cross-sectional study used data from the National Health and Nutrition Examination Survey (1999-2010). The association between general and abdominal obesity (exposure), OA (outcome) and mediators (total cholesterol, high-density lipoprotein, and C-reactive protein) was assessed using multivariate linear and logistic regression models and mediation analysis. Results A total of 23,308 participants were enrolled in this study, and 2,180 were diagnosed with OA. Participants with obesity were more likely to have OA (general obesity: OR=2.508, 95%CI: 1.602, 4.197, P<0.001; abdominal obesity: OR=3.814, 95%CI: 3.242, 4.509, P<0.001) than those without the obesity. High quantile of total cholesterol (OR:1.399; 95%CI:1.235, 1.257; P<0.001), high-density lipoprotein (OR:1.644; 95%CI:1.443, 1.874; P<0.001) and C-reactive protein (OR:1.952; 95%CI:1.707, 2.237; P<0.001) increased the risk of OA when compared to lowest quartile. In the linear regression, the betas varied from 0.668 (95%CI: 0.635, 0.741; P<0.001) to 0.693 (95%CI: 0.674, 0.712; P<0.001), suggesting that individual with obesity had higher C-reactive protein levels. Additionally, total cholesterol and high-density lipoprotein were associated with C-reactive protein. Mediation analyses showed that the causal association of obesity with OA risk was mediated by high-density lipoprotein and C-reactive protein, with the mediation proportion ranging from 17.216 to 45.058%. Moreover, high-density lipoprotein to C-reactive protein path acting as serial mediators in the associations between obesity and OA (general obesity: beta=0.012; 95%CI: 0.009-0.014; abdominal obesity: beta=0.011; 95%CI: 0.008-0.014). Conclusion The association between obesity and OA is partially mediated by systemic inflammation caused by dyslipidemia. Our study suggested anti-lipid therapy may be positive for obese individuals with OA.
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页数：11
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