Vitamin D Level Between Calcium-Phosphorus Homeostasis and Immune System: New Perspective in Osteoporosis

被引：31

作者：

Bellavia, Daniele ^{[1
]}

Costa, Viviana ^{[1
]}

De Luca, Angela ^{[1
]}

Maglio, Melania ^{[2
]}

Pagani, Stefania ^{[3
]}

Fini, Milena ^{[2
]}

Giavaresi, Gianluca ^{[1
]}

机构：

[1] Rizzoli Orthopaed Inst, Innovat Technol Platforms Tissue Engn Theranost &, Via Div 83, I-90100 Palermo, Italy

[2] Rizzoli Orthopaed Inst, Lab Biocompatibil Technol Innovat & Adv Therapies, Bologna, Italy

[3] Rizzoli Orthopaed Inst, Lab Preclin & Surg Studies, Bologna, Italy

来源：

CURRENT OSTEOPOROSIS REPORTS | 2024年 / 22卷 / 06期

关键词：

Vitamin D; Osteoporosis; Calcium-phosphorus homeostasis; Immune system; Polymorphisms; BONE-MINERAL DENSITY; D-BINDING-PROTEIN; D-RECEPTOR GENE; REGULATORY T-CELLS; OBSTRUCTIVE PULMONARY-DISEASE; SERUM 25-HYDROXYVITAMIN D; D-RESPONSE ELEMENT; 1,25-DIHYDROXYVITAMIN D-3; D DEFICIENCY; RHEUMATOID-ARTHRITIS;

D O I：

10.1007/s11914-016-0331-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vitamin D is a key molecule in calcium and phosphate homeostasis; however, increasing evidence has recently shown that it also plays a crucial role in the immune system, both innate and adaptive. A deregulation of vitamin D levels, due also to mutations and polymorphisms in the genes of the vitamin D pathway, determines severe alterations in the homeostasis of the organism, resulting in a higher risk of onset of some diseases, including osteoporosis. This review gives an overview of the influence of vitamin D levels on the pathogenesis of osteoporosis, between bone homeostasis and immune system.

引用

页码：599 / 610

页数：12

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