Comprehensive analysis of the expression and prognostic value of ARMCs in pancreatic adenocarcinoma

被引:0
|
作者
Zhuo, Guanxiang [1 ,2 ]
Lin, Shengzhai [1 ,7 ]
Yuan, Fei [1 ,7 ]
Zheng, Qiaoling [5 ]
Guo, Yinpin [1 ,7 ]
Wang, Zuwei [3 ]
Hu, Jianfei [3 ]
Yao, Meihong [5 ]
Zhong, Fuxiu [6 ]
Chen, Shi [3 ,4 ]
Chen, Yanling [1 ,7 ]
Chen, Huixing [1 ,7 ]
机构
[1] Fujian Med Univ, Fujian Inst Hepatobiliary Surg, Union Hosp, Dept Hepatobiliary Surg, Fuzhou 350001, Fujian, Peoples R China
[2] Fudan Univ, Shanghai Canc Ctr, Xiamen Hosp, Dept Hepatobiliary Surg, Xiamen 350003, Fujian, Peoples R China
[3] Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Fujian, Peoples R China
[4] Fujian Prov Hosp, Dept Hepatopancreatobiliary Surg, Fuzhou 350001, Fujian, Peoples R China
[5] Fujian Med Univ, Union Hosp, Dept Pathol, Fuzhou 350001, Fujian, Peoples R China
[6] Fujian Med Univ, Union Hosp, Dept Hepatobiliary Surg Nursing, Fuzhou 350001, Fujian, Peoples R China
[7] Fujian Med Univ, Canc Ctr, Fuzhou 350001, Fujian, Peoples R China
关键词
Pancreatic adenocarcinoma; Tumor marker; ARMCs; Immune infiltration; Prognostic mode; DROSOPHILA NEUROBLAST; PROLIFERATION; INVASION; CATENIN; KINASE; MIGRATION; PROTEINS; PROMOTES; CELLS;
D O I
10.1186/s12885-024-13365-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundPancreatic adenocarcinoma (PAAD) has a very poor prognosis, and there are few treatments for PAAD. Therefore, it is important to find some biomarkers for the diagnosis and treatment of PAAD. Although some members of Armadillo repeat containing proteins (ARMCs) have been implicated in the development of certain cancers, their relationship with PAAD remains unknown. In this study, we aimed to explore the expression and prognostic value of ARMCs in PAAD.MethodsWe used the The Cancer Genome Atlas (TCGA) database for survival analysis. Then, Gene Expression Profiling Interactive Analysis (GEPIA), the cBioPortal database, the Human Protein Atlas (HPA), Kaplan-Meier Plotter, LinkedOmics Database, Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG), Cytoscape and Timer were used to analyze the relationship between ARMCs and PAAD. In addition, we established a prognostic model of ARMCs for PAAD. Immunohistochemistry (IHC) was also performed. Then Image-J was used to analyze all images obtained from the experiment, and GraphPad-Prism (9.5.1) was used for statistical analysis to verify the expression of ARMCs in PAAD.ResultsIn the TCGA database, the expressions of ARMC1, 2, 3, 5, 6, 7, 8, 9 and 10 in PAAD tissues were significantly higher than those in normal tissues. And higher expressions of ARMC1 and 10 were associated with lower survival rate of PAAD patients. In addition, ARMC2, 5, 6, and 10 were positively associated with advanced stages of PAAD. ARMCs mutations occur in 11% of PAAD patients, and missense mutations and amplification of ARMCs account for most of them. In addition, ARMC5 and ARMC10 were independent prognostic factors in univariate and multivariate Cox regression analyses. Finally, through our confirmation experiment, it was found that the expression of ARMC1 and 10 in PAAD tissues was significantly increased compared with those in paracancer tissue.ConclusionThis study suggests that ARMCs may be able to play important roles in PAAD, and they can act as biomarkers, providing valuable clues for the treatment and diagnosis of PAAD.
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页数:18
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