m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation

被引：0

作者：

Sevim Kahraman ^{[1
]}

Dario F De Jesus ^{[2
]}

Jiangbo Wei ^{[3
]}

Natalie K Brown ^{[1
]}

Zhongyu Zou ^{[2
]}

Jiang Hu ^{[3
]}

Mehdi Pirouz ^{[4
]}

Richard I Gregory ^{[5
]}

Chuan He ^{[7
]}

Rohit N Kulkarni ^{[1
]}

机构：

[1] Joslin Diabetes Center,Islet Cell and Regenerative Biology

[2] Beth Israel Deaconess Medical Center,Department of Medicine

[3] Harvard Medical School,Harvard Stem Cell Institute

[4] Harvard Medical School,Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics

[5] The University of Chicago,Howard Hughes Medical Institute

[6] The University of Chicago,Division of Hematology/Oncology

[7] Boston Children’s Hospital,Department of Chemistry and Department of Biological Sciences

[8] National University of Singapore,undefined

来源：

The EMBO Journal | 2024年 / 43卷 / 22期

关键词：

m; A mRNA Methylation; β-cells; α-cells; Duct Cells; Human Pancreas Development;

D O I：

10.1038/s44318-024-00213-2

中图分类号：

学科分类号：

摘要：

N6-methyladenosine (m6A) is the most abundant chemical modification in mRNA and plays important roles in human and mouse embryonic stem cell pluripotency, maintenance, and differentiation. We have recently reported that m6A is involved in the postnatal control of β-cell function in physiological states and in type 1 and 2 diabetes. However, the precise mechanisms by which m6A acts to regulate the development of human and mouse pancreas are unexplored. Here, we show that the m6A landscape is dynamic during human pancreas development, and that METTL14, one of the m6A writer complex proteins, is essential for the early differentiation of both human and mouse pancreatic cells.

引用

页码：5445 / 5468

页数：23

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