Carboxymethyl cellulose/hydroxyapatite/Fe3O4 bio-nanocomposite hydrogel beads: an efficient oral pH-responsive carrier for doxorubicin delivery

被引：2
作者：
Foroutan, Rauf [1 ]
Mohammadzadeh, Ali [1 ]
Mohammadi, Reza [1 ]
Javanbakht, Siamak [1 ]
机构：
[1] Univ Tabriz, Fac Chem, Dept Organ & Biochem, Polymer Res Lab, Tabriz, Iran
来源：
CHEMICAL PAPERS | 2025年 / 79卷 / 04期
关键词：
Bio-nanocomposite hydrogel; Carboxymethyl cellulose; Doxorubicin; Hydroxyapatite; Oral delivery; DRUG-DELIVERY; MAGNETIC NANOPARTICLES; BIOMEDICAL APPLICATIONS; CELLULOSE NANOWHISKERS; CHITOSAN; FABRICATION; ADSORPTION; REMOVAL; RELEASE; SYSTEMS;
D O I：
10.1007/s11696-025-03944-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, an oral pH-responsive carrier, carboxymethyl cellulose/hydroxyapatite/Fe3O4 bio-nanocomposite hydrogel beads (CMC/HAp/Fe3O4), was prepared to control the release profile of anticancer doxorubicin (DOX) drug. Surface morphology of the CMC/HAp/Fe3O4 bio-nanocomposite hydrogel beads was studied using different techniques. The magnetic measurement studies revealed a good superparamagnetic behavior for the prepared bio-nanocomposite hydrogel beads with a saturation magnetization of 28.73 emu/g. The pH-responsive drug release was verified by in vitro release test and showed a lower release at acidic media (pH 1.2) and a higher release under alkaline conditions (i.e., pH 7.4 and 6.8). Besides, the MTT assay revealed that the DOX-loaded CMC/HAp/Fe3O4 has the desired cytotoxicity against SW480 cells. According to the results, the prepared bio-nanocomposite hydrogel beads have a high potential for being used as biomaterials.
引用
收藏
页码：2461 / 2470
页数：10
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