Lipids associated with autophagy: mechanisms and therapeutic targets

被引：10

作者：

Jarocki, Michal ^{[1
]}

Turek, Kacper ^{[2
]}

Saczko, Jolanta ^{[3
]}

Tarek, Mounir ^{[4
]}

Kulbacka, Julita ^{[3
,5
]}

机构：

[1] Wroclaw Med Univ, Univ Clin Hosp, Wroclaw, Poland

[2] Prov Specialist Hosp, Wroclaw, Poland

[3] Wroclaw Med Univ, Fac Pharm, Dept Mol & Cellular Biol, Wroclaw, Poland

[4] Univ Lorraine, CNRS, LPCT, Nancy, France

[5] State Res Inst Ctr Innovat Med, Dept Immunol & Bioelectrochem, Vilnius, Lithuania

来源：

CELL DEATH DISCOVERY | 2024年 / 10卷 / 01期

关键词：

HEPATIC STELLATE CELLS; ADIPOSE-TISSUE EXPANDABILITY; ENDOPLASMIC-RETICULUM; DOCOSAHEXAENOIC ACID; INDUCTION; OXIAPOPTOPHAGY; IMPACT; DOMAIN; LIVER; PHOSPHATIDYLINOSITOL-3-PHOSPHATE;

D O I：

10.1038/s41420-024-02224-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is a molecular process essential for maintaining cellular homeostasis, with its impairment or dysregulation linked to the progression of various diseases in mammals. Specific lipids, including phosphoinositides, sphingolipids, and oxysterols, play pivotal roles in inducing and regulating autophagy, highlighting their significance in this intricate process. This review focuses on the critical involvement of these lipids in autophagy and lipophagy, providing a comprehensive overview of the current understanding of their functions. Moreover, we delve into how abnormalities in autophagy, influenced by these lipids, contribute to the pathogenesis of various diseases. These include age-related conditions such as cardiovascular diseases, neurodegenerative disorders, type 2 diabetes, and certain cancers, as well as inflammatory and liver diseases, skeletal muscle pathologies and age-related macular degeneration (AMD). This review aims to highlight function of lipids and their potential as therapeutic targets in treating diverse human pathologies by elucidating the specific roles of phosphoinositides, sphingolipids, and oxysterols in autophagy.

引用

页数：11

共 150 条

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