Inflammatory burden index (IBI) and body roundness index (BRI) in gallstone risk prediction: insights from NHANES 2017-2020

被引：0
作者：
Gu, Yuting [1 ]
Zhou, Zhanyi [1 ]
Zhao, Xuan [1 ]
Ye, Xiaolu [1 ]
Qin, Keyi [1 ]
Liu, Jiahui [1 ]
Zhang, Xiao [1 ]
Ji, Yunxi [1 ,2 ]
机构：
[1] Zhejiang Chinese Med Univ, Sch Clin Med 1, Hangzhou 310053, Peoples R China
[2] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Gen Practice, Hangzhou 310053, Peoples R China
来源：
LIPIDS IN HEALTH AND DISEASE | 2025年 / 24卷 / 01期
关键词：
Inflammatory burden index; Body roundness index; Gallstones; Mediation analysis; NHANES; SERUM AMYLOID-A; ADIPOSE-TISSUE; INSULIN-RESISTANCE; GALLBLADDER; CANCER; CHOLESTEROL; DISEASE; EPIDEMIOLOGY; MORTALITY;
D O I：
10.1186/s12944-025-02472-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background The Inflammatory Load Index (IBI) and Body Roundness Index (BRI) were employed to evaluate the systemic inflammatory status and body fat. This study aims to elucidate the association between IBI and the prevalence of gallstones, as well as to analyze the mediating role of BRI in this association. Methods Data from the National Health and Nutrition Examination Survey (NHANES) (2017-2020) were utilized in our cross-sectional study. A total of 2598 participants aged >= 20 years were enrolled. The Boruta algorithm, a supervised classification feature selection method, is leveraged to identify the confounding variables most strongly associated with the prevalence of gallstones. Weighted multivariate logistic regression, restricted cubic splines (RCS), and subgroup analyses were employed to investigate the association between IBI and gallstones, assess the presence of a linear association, and evaluate the effect of IBI on gallstone risk across different populations. Finally, the mediating effect of BRI was examined. Results In the fully adjusted model, when IBI was in the highest tertile, each unit increase in IBI (corresponding to an increase of 1 in the natural logarithm of IBI) was linked to a 110.8% higher prevalence of gallstones (OR = 2.108, 95% CI: 1.109-4.005; P = 0.028). The odds ratio for gallstones increased with higher IBI levels across unadjusted, partially adjusted, and fully adjusted models (P for trend < 0.05). This positive association was confirmed to be linear by the RCS curve (P for nonlinear = 0.887). Subgroup analysis indicated that the risk of gallstones was significantly elevated in individuals aged >= 60, females, and those with a Poverty-to-Income Ratio (PIR) >= 2 (P < 0.05). Mediation analysis revealed that IBI had a significant indirect effect on gallstone prevalence through BRI, with an effect size of 0.0129 (95% CI: 0.0121-0.0136; P < 0.001), and the mediation contributed to 33.24% of the total effect. Conclusions This study demonstrates a significant linear positive relation of IBI to gallstone prevalence. Furthermore, BRI mediates the effect of IBI on gallstone risk. These findings provide a more precise inflammatory marker for gallstone prevention and treatment. Trial registrationNot applicable.
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页数：14
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共 66 条
  • [1] Wang X., Yu W., Jiang G., Li H., Li S., Xie L., Bai X., Cui P., Chen Q., Lou Y., Et al., Global Epidemiology of Gallstones in the 21st Century: a systematic review and Meta-analysis, Clin Gastroenterol Hepatol, 22, pp. 1586-1595, (2024)
  • [2] Stinton L.M., Shaffer E.A., Epidemiology of gallbladder disease: cholelithiasis and cancer, Gut Liver, 6, pp. 172-187, (2012)
  • [3] Unalp-Arida A., Ruhl C.E., Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the US, Hepatology, 77, pp. 1882-1895, (2023)
  • [4] Zhang G., Ding Z., Yang J., Wang T., Tong L., Cheng J., Zhang C., Higher visceral adiposity index was associated with an elevated prevalence of gallstones and an earlier age at first gallstone surgery in US adults: the results are based on a cross-sectional study, Front Endocrinol (Lausanne), 14, (2023)
  • [5] Ryu S., Chang Y., Yun K.E., Jung H.S., Shin J.H., Shin H., Gallstones and the risk of Gallbladder Cancer Mortality: a Cohort Study, Am J Gastroenterol, 111, pp. 1476-1487, (2016)
  • [6] Unalp-Arida A., Ruhl C.E., Burden of gallstone disease in the United States population: prepandemic rates and trends, World J Gastrointest Surg, 16, pp. 1130-1148, (2024)
  • [7] Munoz L.E., Boeltz S., Bilyy R., Schauer C., Mahajan A., Widulin N., Gruneboom A., Herrmann I., Boada E., Rauh M., Krenn V., Biermann M.H.C., Podolska M.J., Hahn J., Knopf J., Maueroder C., Paryzhak S., Dumych T., Zhao Y., Neurath M.F., Hoffmann M.H., Fuchs T.A., Leppkes M., Schett G., Herrmann M., Neutrophil Extracell Traps Initiate Gallstone Formation Immun, 51, 3, pp. 443-e4504, (2019)
  • [8] Leppkes M., Maueroder C., Hirth S., Nowecki S., Gunther C., Billmeier U., Paulus S., Biermann M., Munoz L.E., Hoffmann M., Wildner D., Croxford A.L., Waisman A., Mowen K., Jenne D.E., Krenn V., Mayerle J., Lerch M.M., Schett G., Wirtz S., Neurath M.F., Herrmann M., Becker C., Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis, Nat Commun, 7, (2016)
  • [9] Srikanth E.S., Shreyas M.S., Desai A., Mehdi S., Gangadharappa S., Suman H.V., Krishna K.L., Recent advances, novel targets and treatments for cholelithiasis
  • [10] a narrative review, Eur J Pharmacol, 908, (2021)
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