Gastrectomy after neoadjuvant chemotherapy in five cases of locally advanced gastric cancer with pancreatic head invasion

被引：0
作者：
Kano, Mikihiro [1 ]
Tokumoto, Noriaki [1 ]
Tanabe, Kazuaki [2 ]
Hihara, Jun [1 ]
Toyota, Kazuhiro [3 ]
Hotta, Ryuichi [4 ]
Saeki, Yoshihiro [5 ]
Tazawa, Hirofumi [6 ,7 ]
Fujikuni, Nobuaki [8 ]
Hiroshima Surg Study Grp Clin Oncol HiSCO
机构：
[1] Hiroshima City North Med Ctr Asa Citizens Hosp, Dept Digest Surg, 1-2-1 Kameyama Minami,Asakita Ku, Hiroshima 7310293, Japan
[2] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Perioperat & Crit Care Management, Hiroshima, Japan
[3] Hiroshima Mem Hosp, Dept Surg, Hiroshima, Japan
[4] Higashihiroshima Med Ctr, Natl Hosp Org, Dept Surg, Higashihiroshima, Japan
[5] Hiroshima Univ, Dept Gastroenterol & Transplant Surg, Hiroshima, Japan
[6] Natl Hosp Org Kure Med Ctr, Dept Surg, Kure, Japan
[7] Chugoku Canc Ctr, Kure, Japan
[8] Hiroshima Prefectural Hosp, Dept Digest Surg, Hiroshima, Japan
来源：
INTERNATIONAL CANCER CONFERENCE JOURNAL | 2025年 / 14卷 / 02期
关键词：
Gastric cancer; Neoadjuvant chemotherapy; Pancreatic invasion; OPEN-LABEL; GASTROESOPHAGEAL JUNCTION; PANCREATICODUODENECTOMY; ADENOCARCINOMA; COMPLICATIONS; CAPECITABINE; OXALIPLATIN;
D O I：
10.1007/s13691-025-00750-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Locally advanced gastric cancer (LAGC) with pancreatic head invasion (T4b) carries a poor prognosis despite radical surgery. Herein, we report the effectiveness of neoadjuvant chemotherapy (NAC) in improving the resectability of advanced gastric cancer with pancreatic invasion. A total of 2191 cases of gastric cancer were retrospectively analyzed from 13 institutions within the Hiroshima Surgical Study Group of Clinical Oncology (Hisco) database from 2018 to 2020. Among them, 5 of the 24 patients with Stage cT4b gastric cancer underwent NAC for three-to-eight cycles. Following chemotherapy, three patients underwent total gastrectomy, two patients underwent distal gastrectomy, and no patient underwent pancreaticoduodenectomy (PD). All five patients achieved a chemotherapeutic response of Grade 1b or higher, and only one case showed residual pancreatic invasion on pathology. This study suggests that NAC for Stage T4b LAGC with pancreatic head invasion may have the potential to obviate the need for PD.
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页码：147 / 154
页数：8
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