The molecular pathogenesis of SOX2 in prostate cancer

被引：0

作者：

Liu, Shixue ^{[1
]}

Yu, Honglian ^{[2
]}

Zhao, Zhankui ^{[3
,4
]}

机构：

[1] Jining Med Univ, Jining 272067, Shandong, Peoples R China

[2] Jining Med Univ, Dept Biochem, 133 Hehua Rd, Jining 272067, Shandong, Peoples R China

[3] Jining Med Univ, Affiliated Hosp, Dept Urol, 89 Guhuai Rd, Jining 272029, Shandong, Peoples R China

[4] Shanghai Univ TCM, Peoples Hosp 7, Dept Urol, Shanghai 200137, Peoples R China

来源：

DISCOVER ONCOLOGY | 2025年 / 16卷 / 01期

关键词：

SOX2; Prostate cancer; Pathogenic mechanism; STEM-CELL; MESENCHYMAL TRANSITION; LINEAGE PLASTICITY; SIGNALING PATHWAY; METASTASIS; EXPRESSION; PROLIFERATION; AMPLIFICATION; RESISTANCE; INVASION;

D O I：

10.1007/s12672-025-01972-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

SOX2 is one of the members of the SOX transcription factor family, which is believed to be an important transcription factor that plays a role in embryonic development, maintenance of stem cells, cancer progression, and resistance to cancer treatment. There is increasing evidence suggesting that SOX2 is crucial for the initiation, progression, invasion, metastasis, and treatment resistance of prostate cancer, therefore understanding the mechanism of SOX2 in prostate cancer can provide better targets for the treatment of prostate cancer. This article reviews the structural domains, normal physiological functions, and role in prostate cancer progression of SOX2, providing potential targets for prostate cancer treatment.

引用

页数：13

共 50 条

[31] SOX2 EXPRESSION IN OVARIAN SEROUS EPITHELIAL CANCER
Conic, Irena
Stojnev, Slavica
Velickovic, Ljubinka Jankovic
Djordjevic, Biljana
Dimitrijevic, Aleksandra
Miljan, Krstic
Petrovic, Ana Ristic
Djordjevic, Ivana
Krtinic, Dane
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2020, 30 : A87 - A87
[32] Molecular mechanism of sox2 expression in neural stem cells
Kondo, Toru
NEUROSCIENCE RESEARCH, 2007, 58 : S19 - S19
[33] Functional role of SOX2 in hypoxia-mediated metastasis-associated functions in prostate cancer
Dai, Yao
Bae, Kyung-Mi
Vieweg, Johannes
Siemann, Dietmar W.
CANCER RESEARCH, 2013, 73
[34] Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2
Matsika, Admire
Srinivasan, Bhuvana
Day, Christopher
Mader, Sabrina Ann
Kiernan, Deirdre Margaret
Broomfield, Amy
Fu, Jinlin
Hooper, John D.
Kench, James G.
Samaratunga, Hemamali
PATHOLOGY, 2015, 47 (07) : 622 - 628
[35] SOX2 mediates metabolic reprogramming of prostate cancer cells (vol 41, pg 1190, 2022)
de Wet, Larischa
Williams, Anthony
Gillard, Marc
Kregel, Steven
Lamperis, Sophia
Gutgesell, Lisa C.
Vellky, Jordan E.
Brown, Ryan
Conger, Kelly
Paner, Gladell P.
Wang, Heng
Platz, Elizabeth A.
De Marzo, Angelo M.
Mu, Ping
Coloff, Jonathan L.
Szmulewitz, Russell Z.
Vander Griend, Donald J.
ONCOGENE, 2022, 41 (08) : 1234 - 1234
[36] SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell
Jia, Xianpei
Li, Xuefei
Xu, Yingxi
Zhang, Shu
Mou, Wenjun
Liu, Yanhua
Liu, Yin
Lv, Dan
Liu, Cheng-Hu
Tan, Xiaoyue
Xiang, Rong
Li, Na
JOURNAL OF MOLECULAR CELL BIOLOGY, 2011, 3 (04) : 230 - 238
[37] Role of Foregut Transcription Factor Sox2 in the Pathogenesis of Barrett's Esophagus (BE)
Cenaj, Odise
Srivastava, Amitabh
LABORATORY INVESTIGATION, 2015, 95 : 152A - 152A
[38] SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond
Thorsten Schaefer
Claudia Lengerke
Oncogene, 2020, 39 : 278 - 292
[39] Role of Foregut Transcription Factor Sox2 in the Pathogenesis of Barrett's Esophagus (BE)
Cenaj, Odise
Srivastava, Amitabh
MODERN PATHOLOGY, 2015, 28 : 152A - 152A
[40] Sox2 Is an Androgen Receptor-Repressed Gene That Promotes Castration-Resistant Prostate Cancer
Kregel, Steven
Kiriluk, Kyle J.
Rosen, Alex M.
Cai, Yi
Reyes, Edwin E.
Otto, Kristen B.
Tom, Westin
Paner, Gladell P.
Szmulewitz, Russell Z.
Vander Griend, Donald J.
PLOS ONE, 2013, 8 (01):

← 1 2 3 4 5 →