The molecular pathogenesis of SOX2 in prostate cancer

被引：0

作者：

Liu, Shixue ^{[1
]}

Yu, Honglian ^{[2
]}

Zhao, Zhankui ^{[3
,4
]}

机构：

[1] Jining Med Univ, Jining 272067, Shandong, Peoples R China

[2] Jining Med Univ, Dept Biochem, 133 Hehua Rd, Jining 272067, Shandong, Peoples R China

[3] Jining Med Univ, Affiliated Hosp, Dept Urol, 89 Guhuai Rd, Jining 272029, Shandong, Peoples R China

[4] Shanghai Univ TCM, Peoples Hosp 7, Dept Urol, Shanghai 200137, Peoples R China

来源：

DISCOVER ONCOLOGY | 2025年 / 16卷 / 01期

关键词：

SOX2; Prostate cancer; Pathogenic mechanism; STEM-CELL; MESENCHYMAL TRANSITION; LINEAGE PLASTICITY; SIGNALING PATHWAY; METASTASIS; EXPRESSION; PROLIFERATION; AMPLIFICATION; RESISTANCE; INVASION;

D O I：

10.1007/s12672-025-01972-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

SOX2 is one of the members of the SOX transcription factor family, which is believed to be an important transcription factor that plays a role in embryonic development, maintenance of stem cells, cancer progression, and resistance to cancer treatment. There is increasing evidence suggesting that SOX2 is crucial for the initiation, progression, invasion, metastasis, and treatment resistance of prostate cancer, therefore understanding the mechanism of SOX2 in prostate cancer can provide better targets for the treatment of prostate cancer. This article reviews the structural domains, normal physiological functions, and role in prostate cancer progression of SOX2, providing potential targets for prostate cancer treatment.

引用

页数：13

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