Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort

被引：3

作者：

Tonietto, Matteo ^{[1
]}

Sotolongo-Grau, Oscar ^{[2
]}

Roe-Vellve, Nuria ^{[3
]}

Bullich, Santiago ^{[3
]}

Tartari, Juan Pablo ^{[2
]}

Sanabria, Angela ^{[2
,4
]}

Garcia-Sanchez, Ainhoa ^{[2
]}

Borroni, Edilio ^{[1
]}

Galli, Christopher ^{[1
]}

Perez-Martinez, Esther ^{[3
]}

Castell-Conesa, Joan ^{[5
]}

Roca, Isabel ^{[5
]}

Tarraga, Lluis ^{[2
,4
]}

Ruiz, Agustin ^{[2
,4
]}

Stephens, Andrew W. ^{[3
]}

Boada, Merce ^{[2
,4
]}

Klein, Gregory ^{[1
]}

Marquie, Marta ^{[2
,4
]}

机构：

[1] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharm Res & Early Dev Neurosci & Rare Dis, Basel, Switzerland

[2] Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain

[3] Life Mol Imaging GmbH, Berlin, Germany

[4] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain

[5] SIMM Imagen Med, Barcelona, Spain

来源：

ALZHEIMERS RESEARCH & THERAPY | 2024年 / 16卷 / 01期

关键词：

Tau; Positron emission tomography; 18F]PI-2620; 18F]RO948; FACEHBI; Subjective cognitive decline; Mild cognitive impairment; Alzheimer; BIOMARKERS; RISK;

D O I：

10.1186/s13195-024-01622-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundSecond-generation tau tracers for positron emission tomography (PET) show high affinity for paired helical filaments tau deposits characteristic of Alzheimer<acute accent>s disease and low off-target binding. Differences in their chemical structure though may lead to variations in their regional tau uptake and off-target signal. In this work, we aimed to compare the in-vivo uptake of tau tracers [18F]PI-2620 and [18F]RO948 in the early stages of the AD continuum.MethodsData from the TAU-PET FACEHBI clinical trial (EUDRA-CT 2021-000473-83) were analyzed. All participants were non-demented and underwent tau imaging with [18F]PI-2620 and [18F]RO948 PET within 3 months, amyloid imaging with [18F]Florbetaben and brain magnetic resonance imaging. Tau PET standardized uptake values ratios (SUVR) were calculated in Braak and typical off-target regions using the inferior cerebellar cortex as a reference region.ResultsThe cohort consisted of 18 individuals with subjective cognitive decline (n = 13) and mild cognitive impairment (n = 5), with centiloid values ranging from 17 to 159. Both tau tracers showed similar tau pathology distribution but presented a distinct off-target signal pattern on visual read. SUVR measurements for [18F]PI-2620 and [18F]RO948 were highly correlated in all Braak regions (R2 range [0.65-0.80]). Regarding off-target signal, [18F]PI-2620 had higher SUVRs in vascular structures, and [18F]RO948 had higher SUVRs in the skull/meninges.ConclusionsIn a cohort of individuals at early stages of the AD continuum, tau PET tracers [18F]PI-2620 and [18F]RO948 showed similar in-vivo uptake in all Braak regions and distinct off-target signal. These preliminary results support the development of standardized quantification scales for tau deposition that are tracer-independent.Trial registrationAEMPS EudraCT 2021-000473-83. Registered 30 December 2021.

引用

页数：13

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