Ovarian cancer-derived TGF-β1 induces cancer-associated adipocytes formation by activating SMAD3/TRIB3 pathway to establish pre-metastatic niche

被引：3
作者：
Gao, Tian [1 ,2 ]
Li, Jibin [3 ,4 ]
Cheng, Tianyi [2 ]
Wang, Xingguo [2 ]
Wang, Mengqing [2 ]
Xu, Zhiyang [2 ]
Mu, Yang [2 ]
He, Xianli [1 ]
Xing, Jinliang [3 ,4 ]
Liu, Shujuan [2 ]
机构：
[1] Fourth Mil Med Univ, Tangdu Hosp, Dept Gen Surg, Xian 710038, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Obstet & Gynaecol, Xian 710032, Peoples R China
[3] Fourth Mil Med Univ, State Key Lab Holist Integrat Management Gastroint, Xian 710032, Peoples R China
[4] Fourth Mil Med Univ, Dept Physiol & Pathophysiol, Xian 710032, Peoples R China
来源：
CELL DEATH & DISEASE | 2024年 / 15卷 / 12期
基金：
中国国家自然科学基金;
关键词：
TUMOR MICROENVIRONMENT; TRIBBLES HOMOLOG; TRB3; BETA; DEDIFFERENTIATION; DIFFERENTIATION; PROGRESSION; CONTRIBUTE; INSULIN;
D O I：
10.1038/s41419-024-07311-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ovarian cancer (OC) is prone to adipose tissue metastasis. However, the underlying molecular mechanisms remain elusive. Here, we observed that omental adipocytes were induced into cancer-associated adipocytes (CAAs) by OC-derived TGF-beta 1 to establish a pre-metastatic niche (PMN) through collagen and fibronectin secretion. Mechanistically, OC-derived TGF-beta 1 binds to adipocyte membrane receptors and thus activates intracellular signaling by SMAD3 phosphorylation. The activation of TGF-beta 1/SMAD3 signaling pathway dedifferentiates adipocytes into CAAs by upregulating Tribbles homolog 3 (TRIB3), which suppresses the phosphorylation of CEBP beta. Additionally, CAAs secrete collagen I, collagen VI, and fibronectin to remodel the extracellular matrix and promote the adhesion of OC cells. Pharmacological inhibition of the TGF-beta 1/SMAD3 pathway significantly inhibits CAAs and PMN formation, thereby reducing the OC metastatic burden. Our findings indicate that the formation of CAAs and PMN in adipose tissues facilitates OC cell implantation and blocking the TGF-beta 1/SMAD3 signaling pathway could prevent OC omental metastasis.
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页数：12
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