Exploring the connectivity of dorsolateral prefrontal cortex and the modulatory impact of transcranial magnetic stimulation in adolescents with depression: a focus on pain-related cognitive processing

被引:0
作者
Qiao, Dan [1 ]
Li, Yiran [1 ]
Zhang, Xiaoyu [1 ]
Wen, Yujiao [1 ]
Zhang, Xuemin [1 ]
Ma, Lu [1 ]
Li, Gaizhi [1 ]
Yang, Chunxia [1 ]
Liu, Zhifen [1 ]
机构
[1] Shanxi Med Univ, Hosp 1, Dept Psychiat, 85 Jiefang South Rd, Taiyuan 030001, Peoples R China
关键词
Adolescent depression; Pain; Cognition; Dorsolateral prefrontal cortex; Transcranial magnetic stimulation; RELIABILITY; PERCEPTION; ATTENTION; VIGILANCE; VALIDITY; INSIGHTS; RTMS;
D O I
10.1186/s12888-024-06321-x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
BackgroundAbnormal cognitive response to pain is consistently associated with deleterious outcomes among adolescents with depression. Highly relevant to both pain and cognition, dorsolateral prefrontal cortex (DLPFC) is important to understanding pain cognition. Our study aimed to characterize the circuit of DLPFC and the efficacy of transcranial magnetic stimulation (TMS) over DLPFC on pain cognition in adolescents with depression.MethodsUsing neuroimaging data, we first compared functional connectivity (FC) of DLPFC between 60 adolescents with depression and 65 controls. The patients were then divided into add-on TMS group (N = 30) and Sertraline group (N = 30). Clinical outcome was determined using Pain Vigilance and Awareness Questionnaire (PVAQ) and Pain Catastrophizing Scale (PCS). Finally, we conducted regression analysis to assess the effect that FC of DLPFC contributes to in predicting clinical outcome.ResultsFC analysis showed that compared to controls, patients displayed hyperconnection of left DLPFC - left triangular part of inferior frontal gyrus (IFG), which was significantly correlated with higher PCS total-, magnification- and helplessness-scores. Patients also showed hyperconnection of right DLPFC - right supramarginal gyrus (SMG), which was correlated with lower PCS total- and rumination- scores. After intervention, the add-on TMS group displayed significantly decreased score on PVAQ, PCS total and rumination. FC of left DLPFC - bilateral triangular part of IFG, - right SMG, as well as right DLPFC - left putamen, could predict the improvement of pain vigilance and magnification.ConclusionOur results point to a key role of DLPFC acting as a connection linking cognitive control and pain processing in adolescents with depression.Trial registrationThe study is registered in https://www.chictr.org.cn/ with a registration number ChiCTR2000039503 (date: 10.30.2020).
引用
收藏
页数:13
相关论文
共 44 条
[1]   Pseudohypoalgesia on the Skin A Novel View on the Paradox of Pain Perception in Depression [J].
Baer, Karl-Juergen ;
Terhaar, Janneke ;
Boettger, Michael Karl ;
Boettger, Silke ;
Berger, Sandy ;
Weiss, Thomas .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2011, 31 (01) :103-107
[2]   Depression and pain comorbidity - A literature review [J].
Bair, MJ ;
Robinson, RL ;
Katon, W ;
Kroenke, K .
ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (20) :2433-2445
[3]   Duloxetine A Review of its Pharmacology and Use in Chronic Pain Management [J].
Bellingham, Geoff A. ;
Peng, Philip W. H. .
REGIONAL ANESTHESIA AND PAIN MEDICINE, 2010, 35 (03) :294-303
[4]  
Berlim MT, 2013, PSYCHOL MED, V43, P2245, DOI [10.1017/S0033291712002802, 10.1017/S0033291713000512]
[5]   Induction of Depressed Mood Disrupts Emotion Regulation Neurocircuitry and Enhances Pain Unpleasantness [J].
Berna, Chantal ;
Leknes, Siri ;
Holmes, Emily A. ;
Edwards, Robert R. ;
Goodwin, Guy M. ;
Tracey, Irene .
BIOLOGICAL PSYCHIATRY, 2010, 67 (11) :1083-1090
[6]   Inhibitory Control and the Structural Parcelation of the Right Inferior Frontal Gyrus [J].
Boen, Rune ;
Raud, Liisa ;
Huster, Rene J. .
FRONTIERS IN HUMAN NEUROSCIENCE, 2022, 16
[7]   Potential Role of Pain Catastrophic Thinking in Comorbidity Patients of Depression and Chronic Pain [J].
Chen, Yuanyuan ;
Ju, Peijun ;
Xia, Qingrong ;
Cheng, Peng ;
Gao, Jianliang ;
Zhang, Loufeng ;
Gao, Hua ;
Cheng, Xialong ;
Yu, Tao ;
Yan, Junwei ;
Wang, Qiru ;
Zhu, Cuizhen ;
Zhang, Xulai .
FRONTIERS IN PSYCHIATRY, 2022, 13
[8]   Dimensions of pain catastrophising and specific structural and functional alterations in patients with chronic pain: Evidence in medication-overuse headache [J].
Christidi, Foteini ;
Karavasilis, Efstratios ;
Michels, Lars ;
Riederer, Franz ;
Velonakis, Georgios ;
Anagnostou, Evangelos ;
Ferentinos, Panagiotis ;
Kollias, Spyridon ;
Efstathopoulos, Efstathios ;
Kelekis, Nikolaos ;
Kararizou, Evangelia .
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2020, 21 (10) :726-738
[9]   Control of goal-directed and stimulus-driven attention in the brain [J].
Corbetta, M ;
Shulman, GL .
NATURE REVIEWS NEUROSCIENCE, 2002, 3 (03) :201-215
[10]   Attention to chronic pain is dependent upon pain-related fear [J].
Crombez, G ;
Eccleston, C ;
Baeyens, F ;
Van Houdenhove, B ;
Van den Broeck, A .
JOURNAL OF PSYCHOSOMATIC RESEARCH, 1999, 47 (05) :403-410