Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-4-oxo-2-[(3-ethoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]-thiophen-2-yl)amino]but-2-enoic acids

被引：0

作者：

Parkhoma, K. Yu. ^{[1
]}

Davydenkova, E. D. ^{[1
]}

Makhmudov, R. R. ^{[1
]}

Gorbunova, I. A. ^{[2
]}

Shipilovskikh, D. A. ^{[1
,3
]}

机构：

[1] Perm State Univ, 15 Ul Bukireva, Perm 614990, Russia

[2] ITMO Univ, Build A,49 Kronverksky prosp, St Petersburg 197101, Russia

[3] Perm Natl Res Polytech Univ, 29 Komsomolsky Prosp, Perm 614990, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2024年 / 73卷 / 11期

关键词：

Gewald thiophenes; 2,4-dioxobutanoic acids; 3-(thiophen-2-ylimino)furan-2(3H)-ones; antinociceptive activity; toxicity; in vivo studies; ANTIINFLAMMATORY ACTIVITY; DERIVATIVES; THIENOPYRIMIDINE; THIOPHENE; DESIGN;

D O I：

10.1007/s11172-024-4452-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthetic procedure was developed and the scope of the substituted 4-(het)aryl-2-[(3-ethoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-4-oxobut-2-enoic acids was broadened. Antinociceptive activity and acute toxicity of the synthesized compounds were studied. It was found that the synthesized substituted acids show pronounced antinociceptive activity and were classified as being practically non-toxic.

引用

页码：3359 / 3366

页数：8

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