A privacy-preserving dependable deep federated learning model for identifying new infections from genome sequences

被引:0
|
作者
Mehedi, Sk. Tanzir [1 ]
Abdulrazak, Lway Faisal [2 ,3 ]
Ahmed, Kawsar [4 ,5 ,6 ]
Uddin, Muhammad Shahin [1 ]
Bui, Francis M. [4 ]
Chen, Li [4 ]
Moni, Mohammad Ali [7 ,8 ]
Al-Zahrani, Fahad Ahmed [9 ]
机构
[1] Mawlana Bhashani Sci & Technol Univ, Dept Informat & Commun Technol, Santosh 1902, Tangail, Bangladesh
[2] Middle Tech Univ, Elect Engn Tech Coll, Baghdad, Iraq
[3] Cihan Univ Sulaimaniya, Dept Comp Sci, Sulaimaniya 46001, Kurdistan Regio, Iraq
[4] Univ Saskatchewan, Dept Elect & Comp Engn, 57 Campus Dr, Saskatoon, SK S7N 5A9, Canada
[5] Daffodil Int Univ, Dept Comp Sci & Engn, Hlth Informat Res Lab, Dhaka 1216, Bangladesh
[6] Mawlana Bhashani Sci & Technol Univ, Grp Biophotomati Informat & Commun Technol, Santosh 1902, Tangail, Bangladesh
[7] Charles Sturt Univ, Artificial Intelligence & Cyber Future Inst, AI & Digital Hlth Technol, Bathurst, NSW 2795, Australia
[8] Charles Sturt Univ, Rural Hlth Res Inst, AI & Digital Hlth Technol, Orange, NSW 2800, Australia
[9] Umm Al Qura Univ, Dept Comp Engn, Mecca 24381, Saudi Arabia
来源
SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期
关键词
Deep federated learning; Privacy and security; Dependability; Coronavirus; Genome sequence; NEURAL-NETWORKS;
D O I
10.1038/s41598-025-89612-x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The traditional molecular-based identification (TMID) technique of new infections from genome sequences (GSs) has made significant contributions so far. However, due to the sensitive nature of the medical data, the TMID technique of transferring the patient's data to the central machine or server may create severe privacy and security issues. In recent years, the progression of deep federated learning (DFL) and its remarkable success in many domains has guided as a potential solution in this field. Therefore, we proposed a dependable and privacy-preserving DFL-based identification model of new infections from GSs. The unique contributions include automatic effective feature selection, which is best suited for identifying new infections, designing a dependable and privacy-preserving DFL-based LeNet model, and evaluating real-world data. To this end, a comprehensive experimental performance evaluation has been conducted. Our proposed model has an overall accuracy of 99.12% after independently and identically distributing the dataset among six clients. Moreover, the proposed model has a precision of 98.23%, recall of 98.04%, f1-score of 96.24%, Cohen's kappa of 83.94%, and ROC AUC of 98.24% for the same configuration, which is a noticeable improvement when compared to the other benchmark models. The proposed dependable model, along with empirical results, is encouraging enough to recognize as an alternative for identifying new infections from other virus strains by ensuring proper privacy and security of patients' data.
引用
收藏
页数:24
相关论文
共 24 条
  • [1] Privacy-Preserving Federated Deep Learning With Irregular Users
    Xu, Guowen
    Li, Hongwei
    Zhang, Yun
    Xu, Shengmin
    Ning, Jianting
    Deng, Robert H.
    IEEE TRANSACTIONS ON DEPENDABLE AND SECURE COMPUTING, 2022, 19 (02) : 1364 - 1381
  • [2] Privacy-Preserving Deep Learning
    Shokri, Reza
    Shmatikov, Vitaly
    CCS'15: PROCEEDINGS OF THE 22ND ACM SIGSAC CONFERENCE ON COMPUTER AND COMMUNICATIONS SECURITY, 2015, : 1310 - 1321
  • [3] A Verifiable and Privacy-Preserving Federated Learning Training Framework
    Duan, Haohua
    Peng, Zedong
    Xiang, Liyao
    Hu, Yuncong
    Li, Bo
    IEEE TRANSACTIONS ON DEPENDABLE AND SECURE COMPUTING, 2024, 21 (05) : 5046 - 5058
  • [4] Hercules: Boosting the Performance of Privacy-Preserving Federated Learning
    Xu, Guowen
    Han, Xingshuo
    Xu, Shengmin
    Zhang, Tianwei
    Li, Hongwei
    Huang, Xinyi
    Deng, Robert H.
    IEEE TRANSACTIONS ON DEPENDABLE AND SECURE COMPUTING, 2023, 20 (05) : 4418 - 4433
  • [5] Homomorphic Encryption for Privacy-Preserving Genome Sequences Search
    Oguchi, Masato
    Rohloff, Kurt
    Yamada, Yuki
    2019 IEEE INTERNATIONAL CONFERENCE ON SMART COMPUTING (SMARTCOMP 2019), 2019, : 7 - 12
  • [6] PFA: Privacy-preserving Federated Adaptation for Effective Model Personalization
    Liu, Bingyan
    Guo, Yao
    Chen, Xiangqun
    PROCEEDINGS OF THE WORLD WIDE WEB CONFERENCE 2021 (WWW 2021), 2021, : 923 - 934
  • [7] Privacy-Preserving Defense: Intrusion Detection in IoT using Federated Learning
    Almeida, Leonardo
    Rodrigues, Pedro
    Teixeira, Rafael
    Antunes, Mario
    Aguiar, Rui L.
    2024 IEEE 22ND MEDITERRANEAN ELECTROTECHNICAL CONFERENCE, MELECON 2024, 2024, : 908 - 913
  • [8] Privacy-Preserving Deep Learning via Weight Transmission
    Le Trieu Phong
    Tran Thi Phuong
    IEEE TRANSACTIONS ON INFORMATION FORENSICS AND SECURITY, 2019, 14 (11) : 3003 - 3015
  • [9] Privacy-Preserving Collaborative Deep Learning With Unreliable Participants
    Zhao, Lingchen
    Wang, Qian
    Zou, Qin
    Zhang, Yan
    Chen, Yanjiao
    IEEE TRANSACTIONS ON INFORMATION FORENSICS AND SECURITY, 2020, 15 : 1486 - 1500
  • [10] Privacy-Preserving String Search for Genome Sequences with FHE bootstrapping optimization
    Ishimaki, Yu
    Imabavashi, Hiroki
    Shimizu, Kana
    Yamana, Hayato
    2016 IEEE INTERNATIONAL CONFERENCE ON BIG DATA (BIG DATA), 2016, : 3989 - 3991