Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin

被引：0

作者：

Kim, Ikwhan ^{[1
]}

Jung, Da-Ryung ^{[2
]}

Kim, Ryeong-Hui ^{[3
]}

Lee, Dokyung ^{[3
]}

Jung, Yeongyun ^{[4
]}

Ha, Ji Hoon ^{[5
]}

Lee, Eun Kyung ^{[6
]}

Kim, Jin Mo ^{[5
]}

Kim, Jin Young ^{[5
]}

Jang, Jun-Hwan ^{[7
]}

Bae, Jun-Tae ^{[7
]}

Cho, Yoon Soo ^{[6
]}

Shin, Jae-Ho ^{[1
,3
]}

机构：

[1] Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea

[2] Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea

[3] Kyungpook Natl Univ, NGS Core Facil, Daegu 41566, South Korea

[4] Hallym Univ, Coll Med, Hangang Sacred Heart Hosp, Burn Inst, Seoul 07247, South Korea

[5] Kolmar Korea, R&D Ctr, Seoul 06800, South Korea

[6] Hallym Univ, Coll Med, Hangang Sacred Heart Hosp, Dept Rehabil Med, Seoul 07247, South Korea

[7] J2KBIO, Chungbuk 28104, South Korea

来源：

BMC GENOMIC DATA | 2024年 / 25卷 / 01期

关键词：

<italic>Cutibacterium acnes</italic>; Single-locus sequence typing (SLST); Healthy skin; Whole genome sequencing; <italic>De novo</italic> assembly;

D O I：

10.1186/s12863-024-01277-z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

ObjectivesCutibacterium acnes is a Gram-positive bacterium commonly found on human skin, particularly in sebaceous areas. While it is typically considered a commensal, specific strain types based on single locus sequence typing (SLST) have been associated with pathogenic conditions or healthy skin. Recently, SLST D1 strains, part of phylotype IA1, have received attention for their potential benefits related to skin health. However, their genetic characteristics remain underexplored. Therefore, the whole genome of C. acnes CN6, an SLST D1 strain isolated from the facial skin of a healthy individual, was sequenced to expand the understanding of SLST D1 strains and identify genomic features that may support skin health.Data descriptionThe whole genome sequencing of C. acnes CN6 was conducted using MinION reads based on de novo assembly, revealing a single circular complete chromosome. With the length of 2,550,458 bp and G + C content of 60.04%, the genome contains 2,492 genes, including 2,433 CDSs, 9 rRNAs, 46 tRNAs, 4 ncRNAs, and 134 pseudo genes. Previously predicted virulence proteins of C. ances were detected in the genome. Genome comparation with 200 C. acnes strains isolated from healthy facial skin revealed SLST D1 strain-specific genes and a unique variant of the znuC gene in D1 strains.

引用

页数：4