Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis

被引：0

作者：

Uchino, Motoi ^{[1
]}

Tamura, Koji ^{[2
]}

Nomura, Shinsuke ^{[3
]}

Shinji, Seiichi ^{[4
]}

Kouzu, Keita ^{[5
]}

Shinkawa, Hiroji ^{[6
]}

Ishinuki, Tomohiro ^{[7
]}

Mizuguchi, Toru ^{[7
]}

Ohge, Hiroki ^{[8
]}

Haji, Seiji ^{[9
]}

Shimizu, Junzo ^{[10
]}

Mohri, Yasuhiko ^{[11
]}

Yamashita, Chizuru ^{[12
]}

Kitagawa, Yuichi ^{[13
]}

Suzuki, Katsunori ^{[14
]}

Kobayash, Motomu ^{[15
]}

Kobayashi, Masahiro ^{[16
]}

Hanai, Yuki ^{[17
]}

Nobuhara, Hiroshi ^{[18
]}

Imaoka, Hiroki ^{[19
]}

Yoshida, Masahiro ^{[20
]}

Mayumi, Toshihiko ^{[21
]}

Ikeuchi, Hiroki ^{[1
]}

SSI Prevention Guideline Comm Japan Soc Surgical Infection

机构：

[1] Hyogo Med Univ, Dept Gastroenterol Surg, Div Inflammatory Bowel Dis Surg, 1-1 Mukogawacho, Nishinomiya, Hyogo, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Fukuoka, Japan

[3] Hayamizu Pk Clin, Dept Surg, Miyazaki, Japan

[4] Nippon Med Sch, Dept Gastrointestinal Hepatobiliary Pancreat Surg, Bunkyo, Japan

[5] Natl Def Med Coll, Dept Surg, Tokorozawa, Japan

[6] Osaka Metropolitan Univ, Grad Sch Med, Dept Hepatobiliary Pancreat Surg, Osaka, Japan

[7] Sapporo Med Univ, Dept Nursing, Div Surg Sci, Sapporo, Japan

[8] Hiroshima Univ Hosp, Dept Infect Dis, Hiroshima, Japan

[9] Soseikai Gen Hosp, Dept Surg, Kyoto, Japan

[10] Toyonaka City Hosp, Dept Surg, Osaka, Japan

[11] Mie Prefectural Gen Med Ctr, Dept Gastrointestinal & Gen Surg, 5450-132 Hinaga, Yokaichi, Mie 5148561, Japan

[12] Fujita Hlth Univ, Dept Anesthesiol & Crit Care Med, Toyoake, Aichi, Japan

[13] Natl Ctr Geriatr & Gerontol, Dept Orthopaed Surg, Obu, Aichi, Japan

[14] Hosp Univ Occupat & Environm Hlth, Dept Infect Control, Fukuoka, Japan

[15] Hokushinkai Megumino Hosp, Dept Anesthesiol, Eniwa, Hokkaido, Japan

[16] Kitasato Univ, Res & Educ Ctr Clin Pharm, Sch Pharm, Sagamihara, Kanagawa, Japan

[17] Toho Univ, Fac Pharmaceut Sci, Dept Clin Pharm, Ota, Japan

[18] Hiroshima Prefectural Hosp, Dept Dent, Hiroshima, Japan

[19] Mie Univ, Grad Sch Med, Dept Gastrointestinal & Pediat Surg, Tsu, Mie, Japan

[20] Int Univ Hlth & Welf, Sch Med, Dept Hepatobiliary Pancreat & Gastrointestinal Sur, Otawara 2860124, Japan

[21] Japan Community Healthcare Org Chukyo Hosp, Dept Intens Care Unit, Nagoya, Japan

来源：

BMC SURGERY | 2025年 / 25卷 / 01期

关键词：

Gastrointestinal surgery; Morbidity; Surgical site infections; Antiseptic/antibiotic solution; Wound irrigation; Peritoneal lavage; SURGICAL SITE INFECTIONS; POVIDONE-IODINE; PREVENTION; GUIDELINE; SALINE; TRIAL;

D O I：

10.1186/s12893-025-02774-3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BackgroundSurgical site infections (SSIs) can affect mortality, morbidity, and medical costs. Although it has recently been reported that washing with antiseptic/antibiotic solution can prevent SSI in clean surgery, the clinical impact in gastrointestinal surgery is still uncertain. Therefore, we performed a systematic review and meta-analysis to evaluate the efficacy of antiseptic/antibiotic solution during wound irrigation or peritoneal lavage in gastroenterological surgery.MethodsThe database search used PubMed, MEDLINE, and Cochrane Library. The following inclusion criteria were set for the systematic review. 1) Studies comparing with or without antiseptic/antibiotic irrigation/lavage during gastrointestinal surgery. 2) Studies that described surgical site infections and adverse events. 3) Studies conducted after 2000.ResultsA total of 8 randomized controlled studies (RCTs) and 3 observational studies were included in this meta-analysis. Three RCTs of wound irrigation with povidone iodine (PVI) solution revealed no significant difference between the PVI and control groups [RR 1.41, 95% CI (0.92 to 2.17): p = 0.69]. Three RCTs of peritoneal lavage with antibiotic solution showed no significant difference between the interventional group and control groups [RR 0.39, 95% CI (0.10 to 1.55): p = 0.18]. Regarding other antiseptic or antibiotic solutions, the number of studies and participants were too small for evaluation.ConclusionWound irrigation and peritoneal lavage with antiseptic/antibiotic solution did not have enough efficacy for preventing SSI during gastroenterological surgery.

引用

页数：9

共 29 条

[21] Prophylactic intraoperative wound irrigation with antibiotic solution for the prevention of surgical incisional wound infections: Systematic literature review and meta-analysis [J].