Multi-omics insights into the molecular signature and prognosis of hypopharyngeal squamous cell carcinoma

被引：1

作者：

Ren, Yanxin ^{[1
]}

Xiong, Wei ^{[2
]}

Feng, Chun ^{[3
]}

Yu, Dan ^{[4
,5
]}

Wang, Xiaoyan ^{[6
,7
]}

Yang, Qing ^{[1
]}

Yu, Siting ^{[2
]}

Zhang, Hongjiang ^{[2
]}

Huo, Bangyun ^{[3
]}

Jiang, Honglu ^{[3
]}

Li, Zuli ^{[8
,9
]}

Wang, Junlin ^{[4
,10
]}

Su, Yu-Xiong ^{[10
]}

Yang, Ping ^{[11
]}

Liao, Yong ^{[8
,9
]}

Zhong, Qi ^{[6
,7
]}

Wang, Junwen ^{[4
,5
]}

机构：

[1] Kunming Med Univ, Yunnan Canc Hosp, Dept Hepatobiliary & Pancreat Surg, Affiliated Hosp 3, Kunming, Peoples R China

[2] Kunming Med Univ, Yunnan Canc Hosp, Dept Oncol, Affiliated Hosp 3, Kunming, Peoples R China

[3] Kunming Univ Sci & Technol, Peoples Hosp Yunnan Prov 1, Dept Gastroenterol, Affiliated Hosp, Kunming, Peoples R China

[4] Univ Hong Kong, Fac Dent, Div Appl Oral Sci & Community Dent Care, Hong Kong, Peoples R China

[5] Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Hong Kong, Peoples R China

[6] Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China

[7] Capital Med Univ, Key Lab Otolaryngol Head & Neck Surg, Minist Educ, Beijing, Peoples R China

[8] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Chongqing, Peoples R China

[9] MOE Minist Educ, Key Lab Mol Biol Infect Dis, Chongqing, Peoples R China

[10] Univ Hong Kong, Fac Dent, Div Oral & Maxillofacial Surg, Hong Kong, Peoples R China

[11] Mayo Clin, Dept Quantitat Hlth Sci, Scottsdale, AZ USA

来源：

COMMUNICATIONS BIOLOGY | 2025年 / 8卷 / 01期

基金：

北京市自然科学基金;

关键词：

COMPARATIVE GENOMIC ANALYSIS; HPV-NEGATIVE HEAD; HUMAN-PAPILLOMAVIRUS; TP53; MUTATIONS; NECK; CANCER; P53; DNA; OROPHARYNGEAL; TRANSCRIPTION;

D O I：

10.1038/s42003-025-07700-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Approximately two-thirds of hypopharyngeal squamous cell carcinoma (HPSCC) cases are diagnosed at advanced stages, with the worst prognosis among head and neck squamous cell carcinomas (HNSCCs). Identifying biomarkers for high-risk patients requiring aggressive treatment is crucial. We present mutational, transcriptomic, and proteomic studies of 103 Chinese HPSCC patients and observe a higher prevalence and poorer prognosis in males. Estrogen response pathways are up-regulated, and proteins phosphorylated by protein kinase C (PKC) and cyclin-dependent kinases (CDKs) are aberrantly regulated in HPSCC. We identify aberrant copy number regions including SOX2(3q26.33), FGFR(8p11.23), CCND1(11q13.3), CDKN2A/2B(9p21.3), and MYC(8q24.21). Human papillomavirus (HPV) status combined with highly mutated genes, such as SYNE1 in HPV(-) and MUC4 in HPV(+) patients, were assessed as prognosis markers. A predictive model involving clinical factors and expression of six genes was established and cross-site validated. These findings open new opportunities for stratifying high-risk patients and molecular targets for personalized therapeutic strategies.

引用

页数：14

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