The impact of atopy on the clinical characteristics of mycoplasma pneumoniae pneumonia in pediatric patients

被引：0
作者：
Qin, Yujie [1 ]
Yang, Yuxia [1 ]
Li, Junxiang [1 ]
Guan, Jun [1 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 3, Zhengzhou, Peoples R China
来源：
SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期
关键词：
Mycoplasma pneumoniae pneumonia; Atopy; Children; Severe pneumonia; Bronchiolitis;
D O I：
10.1038/s41598-024-84557-z
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mycoplasma pneumoniae (MP) is one of the pathogens that cause community-acquired pneumonia in children. Atopic diseases are also common in children. However, the impact of atopy on Mycoplasma pneumoniae pneumonia (MPP) in children is still unclear. The purpose of this study is to analyze the impact of atopy on the clinical characteristics of MPP in children, and provide a diagnosis and treatment plan. A total of 489 children hospitalized for MPP in our hospital from June 2023 to December 2023 were selected. They were divided into an atopic group (n = 172) and a non-atopic group (n = 317) based on whether they had atopy or not. Clinical data, treatment regimens, and laboratory indicators were compared between the two groups. Eosinophil count, lactate dehydrogenase and IgE levels were higher in the atopic group than in the non-atopic group. Additionally, neutrophil percentage, procalcitonin levels were lower in the atopic group than in the non-atopic group (P < 0.05). The proportion of bronchiolitis type on lung imaging was higher in the atopic group, and there was a higher incidence of severe pneumonia compared to the non-atopic group (P < 0.05). Atopy may lead to severe MPP and bronchiolitis-type MPP. Therefore, the treatment and prognosis of these children should be given more attention.
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相关论文
共 27 条
[1]   Correlation between chest radiographic findings and clinical features in hospitalized children with Mycoplasma pneumoniae pneumonia [J].
Cho, Yeon Jin ;
Han, Mi Seon ;
Kim, Woo Sun ;
Choim, Eun Hwa ;
Choi, Young Hun ;
Yun, Ki Wook ;
Lee, SeungHyun ;
Cheon, Jung-Eun ;
Kim, In-One ;
Lee, Hoan Jong .
PLOS ONE, 2019, 14 (08)
[2]  
Chunxia C., 2019, Maternal Child. Health Care China, V34, P1085, DOI [10.7620/zgfybj.j.issn.1001-4411.2019.05.39, DOI 10.7620/ZGFYBJ.J.ISSN.1001-4411.2019.05.39]
[3]   Atopy: A Collection of Comorbid Conditions [J].
Diaz-Cabrera, Natalie M. ;
Sanchez-Borges, Mario A. ;
Ledford, Dennis K. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2021, 9 (11) :3862-3866
[4]   Roles of T-cell Immunoglobulin and Mucin Domain Genes and Toll-like Receptors in Wheezy Children with Mycoplasma pneumoniae Pneumonia [J].
Fan, Qing ;
Gu, Tingting ;
Li, Peijie ;
Yan, Ping ;
Chen, Dehong ;
Han, Bingchao .
HEART LUNG AND CIRCULATION, 2016, 25 (12) :1226-1231
[5]  
Haiyan Q., 2019, Chin. J. Pract. Med, V2019, P39
[6]  
Haizhen Y., 2022, J. Mol. Diagn. Therapy, V14, P2040, DOI [10.3969/j.issn.1674-6929.2022.12.006, DOI 10.3969/J.ISSN.1674-6929.2022.12.006]
[7]  
Huaiping Y., 2023, Chin. J. Med. Imaging, V31, P375, DOI [10.3969/j.issn.1005-5185.2023.04.015, DOI 10.3969/J.ISSN.1005-5185.2023.04.015]
[8]   Mycoplasma pneumoniae CARDS Toxin Is Internalized via Clathrin-Mediated Endocytosis [J].
Krishnan, Manickam ;
Kannan, T. R. ;
Baseman, Joel B. .
PLOS ONE, 2013, 8 (05)
[9]  
Kunling H., 2022, Chin. Clin. J. Pract. Pediatr, V37, P909, DOI [10.3760/cma.j.cn101070-20210722-00861, DOI 10.3760/CMA.J.CN101070-20210722-00861]
[10]   Neutrophil-to-lymphocyte ratio as a predictor of poor outcomes of Mycoplasma pneumoniae pneumonia [J].
Li, Dan ;
Gu, Haiyan ;
Chen, Lei ;
Wu, Ruxi ;
Jiang, Yazhou ;
Huang, Xia ;
Zhao, Deyu ;
Liu, Feng .
FRONTIERS IN IMMUNOLOGY, 2023, 14
123