Research progress of ankyrin repeat domain 1 protein: an updated review

被引：1
|
作者：
Xu, Xusan [1 ]
Wang, Xiaoxia [2 ]
Li, Yu [3 ]
Chen, Riling [3 ]
Wen, Houlang [4 ]
Wang, Yajun [5 ]
Ma, Guoda [1 ]
机构：
[1] Guangdong Med Univ, Shunde Women & Children Hosp, Maternal & Child Res Inst, Foshan 528300, Peoples R China
[2] Longjiang Hosp, Dept Neurol, Foshan 528300, Peoples R China
[3] Guangdong Med Univ, Shunde Women & Children Hosp, Dept Pediat, Foshan 528300, Peoples R China
[4] Guangdong Med Univ, Shunde Women & Children Hosp, Med Genet Lab, Foshan 528300, Peoples R China
[5] Guangdong Med Univ, Shunde Women & Children Hosp, Resp Res Inst, Foshan 528300, Peoples R China
来源：
CELLULAR & MOLECULAR BIOLOGY LETTERS | 2024年 / 29卷 / 01期
关键词：
Ankrd1; Cardiovascular diseases; Skeletal muscle diseases; Angiogenesis; Tumor therapy; RNA-SEQUENCING ANALYSIS; GENE-EXPRESSION; TRANSCRIPTIONAL REPRESSOR; CARDIOMYOCYTE APOPTOSIS; CELL-PROLIFERATION; SIGNALING PATHWAY; ANALYSIS REVEALS; HIPPO PATHWAY; UP-REGULATION; CARP GENE;
D O I：
10.1186/s11658-024-00647-w
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ankyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the muscle ankyrin repeat protein (MARP) family. Accumulating evidence has revealed that Ankrd1 plays a crucial role in a wide range of biological processes and diseases. This review consolidates current knowledge on Ankrd1's functions in myocardium and skeletal muscle development, neurogenesis, cancer, bone formation, angiogenesis, wound healing, fibrosis, apoptosis, inflammation, and infection. The comprehensive profile of Ankrd1 in cardiovascular diseases, myopathy, and its potential as a candidate prognostic and diagnostic biomarker are also discussed. In the future, more studies of Ankrd1 are warranted to clarify its role in diseases and assess its potential as a therapeutic target.
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页数：28
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