Photoinduced synthesis of trisubstituted allylic molecules via migratory allylation of olefins

被引：0

作者：

Xia, Dingding ^{[1
,2
]}

Zhang, Na ^{[3
]}

Zhong, Mingdong ^{[4
]}

Wang, Weijie ^{[1
]}

Li, Qiannan ^{[1
,2
]}

Zhang, Yu ^{[1
,2
]}

Zhang, Wei-Dong ^{[1
,2
,5
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai Frontiers Sci Ctr Chinese Med Chem Biol, 1200 Cailun Rd, Shanghai 201203, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, State Key Lab Antiviral Drugs, Pingyuan Lab,NMPA Key Lab Res & Evaluat Innovat Dr, Xinxiang 453007, Henan, Peoples R China

[3] Tongji Univ, Sch Med, Shanghai East Hosp, Dept Lab Med, Shanghai 200120, Peoples R China

[4] Tianjin Normal Univ, Coll Chem, Tianjin Key Lab Struct & Performance Funct Mol, Tianjin 300387, Peoples R China

[5] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2025年 / 61卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC-SYNTHESIS; ALKYLATIONS; ARYLATION; ALDEHYDES; TERTIARY; ACIDS;

D O I：

10.1039/d4cc05368k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A transition-metal-free method to afford diverse trisubstituted allylic molecules via migratory allylation of olefins under light irradiation is described. This system tolerated diverse N-tosylhydrazones and olefinic boronic acids. Successful allylation of drugs and natural-product analogues was achieved. The gram-scale synthesis and subsequent post-transformation demonstrated the potential applications of this strategy.

引用

页码：1653 / 1656

页数：4

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