A bivalent COVID-19 mRNA vaccine elicited broad immune responses and protection against Omicron subvariants infection

被引：1

作者：

Liu, Jun ^{[1
]}

Wang, Li ^{[2
]}

Kurtesi, Alexandra ^{[3
,4
]}

Budylowski, Patrick ^{[5
,6
]}

Potts, Kyle G. ^{[7
,8
,9
,10
]}

Menon, Haritha ^{[1
]}

Tan, Yilin ^{[1
]}

Samaan, Philip ^{[11
]}

Liu, Xinan ^{[2
]}

Wang, Yisen ^{[2
]}

Hu, Queenie ^{[3
,4
]}

Samson, Reuben ^{[3
,4
]}

Qi, Freda ^{[3
,4
]}

Evseev, Danyel ^{[7
,8
,9
,10
]}

John, Cini ^{[7
,8
,9
,10
]}

Ellestad, Kristofor K. ^{[7
,8
,9
,10
]}

Fan, Yue ^{[2
]}

Budiman, Frans ^{[5
]}

Tohan, Ellaine Riczly ^{[5
]}

Udayakumar, Suji ^{[5
]}

Yang, Jennifer ^{[2
]}

Marcusson, Eric G. ^{[1
]}

Gingras, Anne-Claude ^{[3
,4
]}

Mahoney, Douglas J. ^{[7
,8
,9
,10
]}

Ostrowski, Mario A. ^{[5
,6
,11
,12
,13
]}

Martin-Orozco, Natalia ^{[1
]}

机构：

[1] Providence Therapeut Holdings Inc, Calgary, AB, Canada

[2] Everest Med, Shanghai, Peoples R China

[3] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada

[4] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Sinai Hlth Syst, Toronto, ON, Canada

[5] Univ Toronto, Dept Med, Toronto, ON, Canada

[6] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[7] Univ Calgary, Riddell Ctr Canc Immunotherapy, Cumming Sch Med, Calgary, AB, Canada

[8] Univ Calgary, Arnie Charbonneau Canc Inst, Cumming Sch Med, Calgary, AB, Canada

[9] Univ Calgary, Alberta Childrens Hosp Res Inst, Cumming Sch Med, Calgary, AB, Canada

[10] Univ Calgary, Cumming Sch Med, Mol Biol & Microbiol, Immunol & Infect Dis, Calgary, AB, Canada

[11] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[12] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[13] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Unity Hlth Toronto, Toronto, ON, Canada

来源：

NPJ VACCINES | 2025年 / 10卷 / 01期

关键词：

SARS-COV-2; INFECTION; T-CELLS; BOOSTER; EVASION; VARIANT; MEMORY;

D O I：

10.1038/s41541-025-01062-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Continuously emerging SARS-CoV-2 Omicron subvariants pose a threat thwarting the effectiveness of approved COVID-19 vaccines. Especially, the protection breadth and degree of these vaccines against antigenically distant Omicron subvariants is unclear. Here, we report the immunogenicity and efficacy of a bivalent mRNA vaccine, PTX-COVID19-M1.2 (M1.2), which encodes native spike proteins from Wuhan-Hu-1 (D614G) and Omicron BA.2.12.1, in mouse and hamster models. Both primary series and booster vaccination using M1.2 elicited potent and broad nAbs against Wuhan-Hu-1 (D614G) and some Omicron subvariants. Strong spike-specific T cell responses against Wuhan-Hu-1 and Omicron subvariants, including JN.1, were also induced. Vaccination with M1.2 protected animals from Wuhan-Hu-1 and multiple Omicron subvariants challenges. Interestingly, protection against XBB.1.5 lung infection did not correlate with nAb levels. These results indicate that M1.2 generated a broadly protective immune response against antigenically distant Omicron subvariants, and spike-specific T cells probably contributed to the breadth of the protection.

引用

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