1,1,1,3,3,3-hexafluoro-2-propanol as a reusable media: Green and catalyst-free synthesis of pyrano[2,3-d]pyrimidine scaffolds

A safe method of producing pyrano[2,3-d]pyrimidine scaffolds without the need for a catalyst is shown, utilizing the concepts of green chemistry. This is achieved by employing polyfluorinated alcohol as a reusable medium and mixing barbituric acid/1,3-dimethylbarbituric acid, malononitrile and aryl aldehydes in an environmentally friendly manner. This environmentally friendly method uses one pot, readily accessible, low-cost reaction media, safe reaction conditions, no requirement for column chromatography for separation and effective use of resources. Furthermore, green 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) did not require significant modifications and remained stable for four reuses. This is highly helpful in satisfying industrial demands and resolving environmental issues.Graphical abstractOur study shows that 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) is used as a reusable medium to synthesize pyrano[2,3-d]pyrimidine frameworks without the need for a catalyst. This eco-friendly, cost-effective and straightforward solution has several benefits. It employs readily accessible materials, reduces the need for costly and dangerous chemicals, saves time and yields high-quality results.