Synthesis, Characterization, and Molecular Docking Studies of Chalcone-Based Imidazole Derivatives as Potential Antioxidant Agents

被引：0
|
作者：
Kamel, R. J. [1 ]
Abdul-Rida, N. A. [2 ]
机构：
[1] Al Qadisiyah Univ, Coll Pharm, Dept Pharmaceut Chem, Al Diwaniyah 58002, Iraq
[2] Univ Al Qadisiyah, Coll Sci, Dept Chem, Al Diwaniyah 58002, Iraq
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2025年 / 95卷 / 03期
关键词：
chalcone; antioxidant; molecular docking; imidazole; free radicals; STRUCTURAL-CHARACTERIZATION; OXIDATIVE STRESS; ANTICANCER; DESIGN;
D O I：
10.1134/S1070363225600043
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AbstractThis study focuses on the synthesis of novel organic compounds with potential antioxidant activity. The intermediate hydroxychalcone derivative was synthesized via Claisen-Schmidt condensation and then reacted with chloroacetamide derivatives to produce the target compounds. The biological activity of these compounds was evaluated in vitro by DPPH assay and theoretically using molecular docking. The results obtained support the tested compounds' importance in free radical scavenging which showed promising inhibitory potential against free radical. The high inhibition percentages of these compounds (up to 88.8% at a concentration of 500 mu M) compared to ascorbic acid may be due to their structural properties attracting to the free radicals.
引用
收藏
页码：715 / 721
页数：7
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