Synthesis, Characterization, and Molecular Docking Studies of Chalcone-Based Imidazole Derivatives as Potential Antioxidant Agents

AbstractThis study focuses on the synthesis of novel organic compounds with potential antioxidant activity. The intermediate hydroxychalcone derivative was synthesized via Claisen-Schmidt condensation and then reacted with chloroacetamide derivatives to produce the target compounds. The biological activity of these compounds was evaluated in vitro by DPPH assay and theoretically using molecular docking. The results obtained support the tested compounds' importance in free radical scavenging which showed promising inhibitory potential against free radical. The high inhibition percentages of these compounds (up to 88.8% at a concentration of 500 mu M) compared to ascorbic acid may be due to their structural properties attracting to the free radicals.