NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control

被引：3

作者：

Imai, Shin-ichiro ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Dev Biol, Dept Med Joint, St Louis, MO 63130 USA

[2] Inst Res Prod Aging IRPA, Tokyo, Japan

来源：

NPJ AGING | 2025年 / 11卷 / 01期

关键词：

NICOTINAMIDE MONONUCLEOTIDE; LIFE-SPAN; MITOCHONDRIAL DYSFUNCTION; INSULIN-SECRETION; SALVAGE PATHWAY; GENE-EXPRESSION; SLC12A8; ENCODES; LIPID DROPLETS; METABOLISM; NAMPT;

D O I：

10.1038/s41514-025-00192-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Over the past five years, systemic NAD+ (nicotinamide adenine dinucleotide) decline has been accepted to be a key driving force of aging in the field of aging research. The original version of the NAD World concept was proposed in 2009, providing an integrated view of the NAD+-centric, systemic regulatory network for mammalian aging and longevity control. The reformulated version of the concept, the NAD World 2.0, was then proposed in 2016, emphasizing the importance of the inter-tissue communications between the hypothalamus and peripheral tissues including adipose tissue and skeletal muscle. There has been significant progress in our understanding of the importance of nicotinamide mononucleotide (NMN), a key NAD+ intermediate, and nicotinamide phosphoribosyltransferase (NAMPT), particularly extracellular NAMPT (eNAMPT). With these exciting developments, the further reformulated version of the concept, the NAD World 3.0, is now proposed, featuring multi-layered feedback loops mediated by NMN and eNAMPT for mammalian aging and longevity control.

引用

页数：12

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