Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article

被引：11

作者：

Mehdi, Syed Faizan ^{[1
]}

Qureshi, Muhammad Hamza ^{[1
]}

Pervaiz, Salman ^{[1
]}

Kumari, Karishma ^{[1
]}

Saji, Edwin ^{[1
]}

Shah, Mahnoor ^{[1
]}

Abdullah, Ahmad ^{[1
]}

Zahoor, Kamran ^{[1
]}

Qadeer, Hafiza Amna ^{[1
]}

Katari, Disha Kumari ^{[1
]}

Metz, Christine ^{[1
]}

Mishra, Lopa ^{[1
]}

Leroith, Derek ^{[2
]}

Tracey, Kevin ^{[1
]}

Brownstein, Michael J. ^{[3
]}

Roth, Jesse ^{[1
]}

机构：

[1] Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY 11030 USA

[2] Icahn Sch Med Mt Sinai, Div Endocrinol Diabet & Bone Dis, New York, NY USA

[3] Azevan Pharmaceut Inc, Bethlehem, PA USA

来源：

MOLECULAR MEDICINE | 2025年 / 31卷 / 01期

关键词：

Inflammation; Sepsis; Septic shock; Metabolism; Hormones; Endocrine; INTENSIVE INSULIN THERAPY; NONTHYROIDAL ILLNESS SYNDROME; CRITICALLY-ILL PATIENTS; MYOFIBRILLAR PROTEIN BREAKDOWN; EUTHYROID SICK SYNDROME; PITUITARY-ADRENAL AXIS; BLOOD-GLUCOSE CONTROL; TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-I; FACTOR-KAPPA-B;

D O I：

10.1186/s10020-025-01074-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Severe sepsis is cognate with life threatening multi-organ dysfunction. There is a disturbance in endocrine functions with alterations in several hormonal pathways. It has frequently been linked with dysfunction in the hypothalamic pituitary-adrenal axis (HPA). Increased cortisol or cortisolemia is evident throughout the acute phase, along with changes in the hypothalamic pituitary thyroid (HPT) axis, growth hormone-IGF-1 axis, insulin-glucose axis, leptin, catecholamines, renin angiotensin aldosterone axis, ghrelin, glucagon, hypothalamic pituitary gonadal (HGA) axis, and fibroblast growth factor-21. These changes and metabolic alterations constitute the overall response to infection in sepsis. Further research is essential to look into the hormonal changes that occur during sepsis, not only to understand their potential relevance in therapy but also because they may serve as prognostic indicators.

引用

页数：21

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