Association between genetically predicted leisure and social activities and cardiovascular disease and other health outcomes

被引：0

作者：

Kim, Soyeon ^{[1
,2
,3
]}

Ko, Hyunwoong ^{[1
]}

Myung, Woojae ^{[2
,4
]}

Yoon, Joohyun ^{[2
]}

Kim, Kiwon ^{[5
]}

Jung, Sang-Hyuk ^{[1
]}

Shim, Injeong ^{[1
]}

Cha, Soojin ^{[1
]}

Kim, Beomsu ^{[1
]}

Kang, Jae Myeong ^{[6
]}

Park, Woong-Yang ^{[7
]}

Natarajan, Pradeep ^{[8
,9
,10
]}

Do, Ron ^{[11
,12
]}

Won, Hong-Hee ^{[1
,7
]}

机构：

[1] Sungkyunkwan Univ, Samsung Med Ctr, Samsung Adv Inst Hlth Sci & Technol SAIHST, Seoul, South Korea

[2] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Seongnam, South Korea

[3] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA USA

[4] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea

[5] Hallym Univ, Coll Med, Kangdong Sacred Heart Hosp, Dept Psychiat, Seoul 134701, South Korea

[6] Gachon Univ, Gil Med Ctr, Dept Psychiat, Incheon, South Korea

[7] Sungkyunkwan Univ, Sch Med, Samsung Genome Inst, Samsung Med Ctr, Seoul, South Korea

[8] Broad Inst Harvard & MIT, Med & Populat Genet & Cardiovasc Dis Initiat, Cambridge, MA USA

[9] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA USA

[10] Harvard Med Sch, Dept Med, Boston, MA USA

[11] Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY USA

[12] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA

来源：

NATURE CARDIOVASCULAR RESEARCH | 2025年 / 4卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

GENOME-WIDE ASSOCIATION; MENDELIAN RANDOMIZATION; PHYSICAL-ACTIVITY; BLOOD-PRESSURE; VARIANTS; METAANALYSIS; INSTRUMENTS; TIME; BIAS; HERITABILITY;

D O I：

10.1038/s44161-024-00581-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Participation in leisure and social activities (LSA) is associated with better health outcomes and lower mortality1, 2-3. Previous observational studies demonstrated a relationship between engagement in LSA and both mental and physical health4,5. Although several studies6 examined the association between LSA and health outcomes, including cardiovascular disease, their possible causal relationship has not been studied. In this study, we investigated the causal relationship between LSA and various health outcomes, including cardiovascular disease, using data from genome-wide association study summary statistics (sample size = 63,926-1,557,411) and a Mendelian randomization approach. Genetically predicted LSA were associated with a reduced risk of several health outcomes, including coronary artery disease and coronary atherosclerosis. Mediation analysis indicated that these effects were partly mediated by modifiable risk factors, such as body mass index, smoking and lipid levels. These findings highlight the importance of LSA in disease prevention and health promotion.

引用

页码：15 / 25

页数：28

共 71 条

[1] The GTEx Consortium atlas of genetic regulatory effects across human tissues [J].

Aguet, Francois ;

Barbeira, Alvaro N. ;

Bonazzola, Rodrigo ;

Brown, Andrew ;

Castel, Stephane E. ;

Jo, Brian ;

Kasela, Silva ;

Kim-Hellmuth, Sarah ;

Liang, Yanyu ;

Parsana, Princy ;

Flynn, Elise ;

Fresard, Laure ;

Gamazon, Eric R. ;

Hamel, Andrew R. ;

He, Yuan ;

Hormozdiari, Farhad ;

Mohammadi, Pejman ;

Munoz-Aguirre, Manuel ;

Ardlie, Kristin G. ;

Battle, Alexis ;

Bonazzola, Rodrigo ;

Brown, Christopher D. ;

Cox, Nancy ;

Dermitzakis, Emmanouil T. ;

Engelhardt, Barbara E. ;

Garrido-Martin, Diego ;

Gay, Nicole R. ;

Getz, Gad ;

Guigo, Roderic ;

Hamel, Andrew R. ;

Handsaker, Robert E. ;

He, Yuan ;

Hoffman, Paul J. ;

Hormozdiari, Farhad ;

Im, Hae Kyung ;

Jo, Brian ;

Kasela, Silva ;

Kashin, Seva ;

Kim-Hellmuth, Sarah ;

Kwong, Alan ;

Lappalainen, Tuuli ;

Li, Xiao ;

Liang, Yanyu ;

MacArthur, Daniel G. ;

Mohammadi, Pejman ;

Montgomery, Stephen B. ;

Munoz-Aguirre, Manuel ;

Rouhana, John M. ;

Hormozdiari, Farhad ;

Im, Hae Kyung .

SCIENCE, 2020, 369 (6509) :1318-1330

[2] Leisure Time Physical Activity and Mortality A Detailed Pooled Analysis of the Dose-Response Relationship [J].

Arem, Hannah ;

Moore, Steven C. ;

Patel, Alpa ;

Hartge, Patricia ;

de Gonzalez, Amy Berrington ;

Visvanathan, Kala ;

Campbell, Peter T. ;

Freedman, Michal ;

Weiderpass, Elisabete ;

Adami, Hans Olov ;

Linet, Martha S. ;

Lee, I. -Min ;

Matthews, Charles E. .

JAMA INTERNAL MEDICINE, 2015, 175 (06) :959-967

[3] 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Part 1, Lifestyle and Behavioral Factors [J].

Arnett, Donna K. ;

Khera, Amit ;

Blumenthal, Roger S. .

JAMA CARDIOLOGY, 2019, 4 (10) :1043-1044

[4] Exercise treatment for major depression: Maintenance of therapeutic benefit at 10 months [J].

Babyak, M ;

Blumenthal, JA ;

Herman, S ;

Khatri, P ;

Doraiswamy, M ;

Moore, K ;

Craighead, E ;

Baldewicz, TT ;

Krishnan, KR .

PSYCHOSOMATIC MEDICINE, 2000, 62 (05) :633-638

[5] Efficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes [J].

Bi, Wenjian ;

Zhou, Wei ;

Dey, Rounak ;

Mukherjee, Bhramar ;

Sampson, Joshua N. ;

Lee, Seunggeun .

AMERICAN JOURNAL OF HUMAN GENETICS, 2021, 108 (05) :825-839

[6] Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator [J].

Bowden, Jack ;

Smith, George Davey ;

Haycock, Philip C. ;

Burgess, Stephen .

GENETIC EPIDEMIOLOGY, 2016, 40 (04) :304-314

[7] Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression [J].

Bowden, Jack ;

Smith, George Davey ;

Burgess, Stephen .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2015, 44 (02) :512-525

[8] An atlas of genetic correlations across human diseases and traits [J].

Bulik-Sullivan, Brendan ;

Finucane, Hilary K. ;

Anttila, Verneri ;

Gusev, Alexander ;

Day, Felix R. ;

Loh, Po-Ru ;

Duncan, Laramie ;

Perry, John R. B. ;

Patterson, Nick ;

Robinson, Elise B. ;

Daly, Mark J. ;

Price, Alkes L. ;

Neale, Benjamin M. .

NATURE GENETICS, 2015, 47 (11) :1236-+

[9] The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 [J].

Buniello, Annalisa ;

MacArthur, Jacqueline A. L. ;

Cerezo, Maria ;

Harris, Laura W. ;

Hayhurst, James ;

Malangone, Cinzia ;

McMahon, Aoife ;

Morales, Joannella ;

Mountjoy, Edward ;

Sollis, Elliot ;

Suveges, Daniel ;

Vrousgou, Olga ;

Whetzel, Patricia L. ;

Amode, Ridwan ;

Guillen, Jose A. ;

Riat, Harpreet S. ;

Trevanion, Stephen J. ;

Hall, Peggy ;

Junkins, Heather ;

Flicek, Paul ;

Burdett, Tony ;

Hindorff, Lucia A. ;

Cunningham, Fiona ;

Parkinson, Helen .

NUCLEIC ACIDS RESEARCH, 2019, 47 (D1) :D1005-D1012

[10]

Burgess S, 2015, Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation

← 1 2 3 4 5 6 7 8 →