Organic Catalytic Oxa-Michael-Aldol Cascade Reaction for the Asymmetric Synthesis of (R)-2-Phenyl-2H-chromene-3-carbaldehyde

被引：0

作者：

Li, Chonglong ^{[1
,2
,3
]}

Chen, Chaoxing ^{[1
]}

Zhan, Murong ^{[1
]}

Wang, Zixuan ^{[1
]}

Wang, Shuyi ^{[1
]}

机构：

[1] North Minzu Univ, Sch Chem & Chem Engn, Yinchuan 750021, Peoples R China

[2] North Minzu Univ, Ningxia Key Lab Solar Chem Convers Technol, Yinchuan 750021, Ningxia, Peoples R China

[3] North Minzu Univ, Key Lab Chem Engn & Technol, State Ethn Affairs Commiss, Yinchuan 750021, Peoples R China

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / SUPPL1期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; cyclohexanediamine catalyst; oxa-Michael-aldol cascade reaction; organocatalyst; ORGANOCATALYTIC SYNTHESIS; STEREOCENTERS; DERIVATIVES; INHIBITORS; CHROMENES; DESIGN; ETHER;

D O I：

10.1134/S1070428024130189

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalyzed by a chiral cyclohexanediamine-based organocatalyst, the asymmetric oxa-Michael-aldol cascade reaction of salicylaldehyde and cinnamaldehyde was studied to synthesize benzopyran derivatives. Using (1R,2R)-N-1,N-1-dimethylcyclohexane-1,2-diamine (Cat 1) as the catalyst, the synthesized chiral 2-aryl-2H-chromenes-3-carbaldehyde exhibits high yields (up to 85%) and with enantioselectivity (ee) values of 35.4%. The high yield and mild reaction conditions are some of the important features of this protocol.

引用

页码：S140 / S146

页数：7

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