Modeling of Isoproterenol-Induced Chronic Heart Failure in 24-Month-Old Rats

被引：0

作者：

Rebrova, T. Yu. ^{[1
]}

Korepanov, V. A. ^{[1
]}

Stepanov, I. V. ^{[1
]}

Afanasiev, S. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Cardiol Res Inst, Tomsk Natl Res Med Ctr, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年 / 178卷 / 01期

关键词：

isoproterenol; chronic heart failure; rats;

D O I：

10.1007/s10517-024-06277-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The development of chronic heart failure (CHF) was induced in 24-month-old male Wistar rats weighing 550-600 g by 4 subcutaneous injections of isoproterenol hydrochloride (ISO) at a dose of 10 mg/kg with 3-day intervals. The control group received injections of saline. The rats were euthanized 60 days after the last ISO/saline injection. The mortality rate in the group of rats with CHF was 30%. Histological studies showed morphological changes in the myocardium, kidneys, and lungs typical of CHF. The presented scheme of ISO administration can be used for modeling CHF in 24-month-old rats.

引用

页码：30 / 33

页数：4

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