Circular RNA NINL accelerates the malignant progression of cervical cancer

被引：0
作者：
Cao, Chengcheng [1 ]
Zhang, Haifeng [1 ]
Zhang, Ting [2 ]
Nie, Cuicui [2 ]
机构：
[1] Shandong Second Med Univ, Dept Oncol, Affiliated Hosp, Weifang, Shandong, Peoples R China
[2] Sunshine Union Hosp, Dept Gynecol & Obstet, 9000 Yingqian St,High Tech Zone, Weifang 261000, Shandong, Peoples R China
来源：
DISCOVER ONCOLOGY | 2024年 / 15卷 / 01期
关键词：
Cervical cancer; CircNINL; miR-2467-3p; Specificity protein 1;
D O I：
10.1007/s12672-024-01588-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
ObjectiveThe study's aim was to explore a novel miRNA/mRNA network mediated by circNINL in cervical cancer (CC).MethodsTumor tissue specimens and normal tissue specimens of 86 CC patients were collected. CircNINL, miR-2467-3p, and specificity protein 1 (SP1) expression levels in tissues were detected. In Hela cells, transfection was implemented to determine whether CircNINL, miR-2467-3p and SP1 regulated cellular progression. The interaction between circNINL, miR-2467-3p, and SP1 was explored.ResultsCircNINL and SP1 were abnormally increased whereas miR-2467-3p expression was suppressed in CC. Functionally, circNINL silencing or miR-2467-3p overexpression reduced CC cell progression, whereas circNINL overexpression did the opposite. CircNINL had a spongy effect on miR-2467-3p to regulate SP1 levels. miR-2467-3p inhibition or SP1 overexpression offset the inhibitory effect of circNINL silence on CC malignant progression.ConclusionCircNINL silencing can increase miR-2467-3p, thereby inducing the downregulation of SP1, thereby suppressing CC progression.
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页数：13
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