Effects of laparoscopic sleeve gastrectomy on weight loss and metabolic improvement in subjects aged 65 years or older: a subanalysis of J-SMART study

被引：0

作者：

Watanabe, Yasuhiro ^{[1
]}

Yamaguchi, Takashi ^{[1
,2
]}

Sasaki, Akira ^{[3
]}

Naitoh, Takeshi ^{[4
]}

Matsubara, Hisahiro ^{[5
]}

Yokote, Koutaro ^{[6
]}

Okazumi, Shinichi ^{[7
,8
]}

Ugi, Satoshi ^{[9
,10
]}

Yamamoto, Hiroshi ^{[11
]}

Ohta, Masayuki ^{[12
,13
]}

Ishigaki, Yasushi ^{[14
]}

Kasama, Kazunori ^{[15
]}

Seki, Yosuke ^{[15
]}

Tsujino, Motoyoshi ^{[16
]}

Shirai, Kohji ^{[17
]}

Miyazaki, Yasuhiro ^{[18
]}

Masaki, Takayuki ^{[19
]}

Nagayama, Daiji ^{[1
,20
]}

Tatsuno, Ichiro ^{[1
,21
]}

Saiki, Atsuhito ^{[1
]}

机构：

[1] Toho Univ, Sakura Med Ctr, Ctr Diabet Endocrinol & Metab, Sakura, Chiba, Japan

[2] Misaki Clin Internal Med, Yotsukaido, Chiba, Japan

[3] Iwate Med Univ, Sch Med, Dept Surg, Yahaba, Iwate, Japan

[4] Kitasato Univ, Dept Lower Gastrointestinal Surg, Sch Med, Sagamihara, Kanagawa, Japan

[5] Chiba Univ, Grad Sch Med, Dept Frontier Surg, Chiba, Chiba, Japan

[6] Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Chiba, Japan

[7] Japan Community Hlth Care Org, Chiba Hosp, Chiba, Chiba, Japan

[8] Toho Univ, Sakura Med Ctr, Dept Surg, Sakura, Chiba, Japan

[9] Shiga Univ Med Sci, Dept Med, Otsu, Shiga, Japan

[10] Omihachiman Community Med Ctr, Dept Gastroenterol, Omihachiman, Shiga, Japan

[11] Japan Community Hlth Care Org, Shiga Hosp, Dept Weight Loss & Metab Surg, Otsu, Shiga, Japan

[12] Oita Univ, Res Ctr Global & Local Infect Dis, Yufu, Oita, Japan

[13] Oita Univ, Fac Med, Dept Gastroenterol & Pediat Surg, Yufu, Oita, Japan

[14] Iwate Med Univ, Dept Internal Med, Div Diabet Metab & Endocrinol, Yahaba, Iwate, Japan

[15] Yotsuya Med Cube, Weight Loss & Metab Surg Ctr, Tokyo, Tokyo, Japan

[16] Tokyo Metropolitan Tama Med Ctr, Dept Endocrinol & Metab, Fuchu, Tokyo, Japan

[17] Mihama Hosp, Dept Internal Med, Chiba, Chiba, Japan

[18] Osaka Gen Med Ctr, Dept Surg, Osaka, Osaka, Japan

[19] Oita Univ, Fac Med, Dept Endocrinol Metab Rheumatol & Nephrol, Yufu, Oita, Japan

[20] Nagayama Clin, Oyama, Tochigi, Japan

[21] Chiba Prefecture Univ Hlth Sci, Chiba, Chiba, Japan

来源：

DIABETOLOGY INTERNATIONAL | 2025年 / 16卷 / 01期

关键词：

Obesity; Laparoscopic sleeve gastrectomy; Diabetes; Older adults; BARIATRIC SURGERY; C-PEPTIDE; INSULIN; INDEX;

D O I：

10.1007/s13340-024-00767-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: To investigate the effect of weight loss and metabolic improvement after laparoscopic sleeve gastrectomy (LSG) in older adults aged 65 years or over compared with younger adults in a retrospective analysis. Methods: The J-SMART study database of 322 Japanese individuals with body mass index (BMI) >= 32 kg/m(2) who underwent LSG between 2011 and 2014 at 10 centers accredited by the Japanese Society for Treatment of Obesity were analyzed. The subjects were classified into two groups: >= 65 age group (range, 65-76 years; n = 25) and <65 age group (range, 22-64 years; n = 297). Clinical parameters were compared between the groups. Results: Baseline data for the >= 65 vs. <65 age groups were: median age 67 years vs. 45 years; weight 92.7 kg vs. 114.4 kg; BMI 40.0 kg/m(2) vs. 41.9 kg/m(2); and HbA1c 6.8% vs. 6.5%. The >= 65 age group had significantly lower preoperative weight, BMI, estimated glomerular filtration rate, and ABCD score, but higher visceral fat area and prevalence of diabetes, hypertension, and obstructive sleep apnea (OSAS). Weight was significantly reduced in both groups throughout 5 years post-LSG, though total weight loss at 2 years was lower in the >= 65 age group (28.0%) than in the <65 group (30.0%). Remission rates of diabetes, hypertension, OSAS, and joint disorders 2 years after LSG showed no significant differences, except for dyslipidemia. Conclusion: LSG may be an efficacious option for improving obesity-related health problems in older adults. However, postoperative safety and complications were not evaluated in this study and further research is needed.

引用

页码：56 / 64

页数：9

共 31 条

[1] Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study [J].

Ahuja, Vasudha ;

Kadowaki, Takashi ;

Evans, Rhobert W. ;

Kadota, Aya ;

Okamura, Tomonori ;

El Khoudary, Samar R. ;

Fujiyoshi, Akira ;

Barinas-Mitchell, Emma J. M. ;

Hisamatsu, Takashi ;

Vishnu, Abhishek ;

Miura, Katsuyuki ;

Maegawa, Hiroshi ;

El-Saed, Aiman ;

Kashiwagi, Atsunori ;

Kuller, Lewis H. ;

Ueshima, Hirotsugu ;

Sekikawa, Akira .

DIABETOLOGIA, 2015, 58 (02) :265-271

[2] Sleep Apnea Syndrome (SAS) Clinical Practice Guidelines 2020 [J].

Akashiba, Tsuneto ;

Inoue, Yuichi ;

Uchimura, Naohisa ;

Ohi, Motoharu ;

Kasai, Takatoshi ;

Kawana, Fusae ;

Sakurai, Shigeru ;

Takegami, Misa ;

Tachikawa, Rho ;

Tanigawa, Takeshi ;

Chiba, Shintaro ;

Chin, Kazuo ;

Tsuiki, Satoru ;

Tonogi, Morio ;

Nakamura, Hiroshi ;

Nakayama, Takeo ;

Narui, Koji ;

Yagi, Tomoko ;

Yamauchi, Motoo ;

Yamashiro, Yoshihiro ;

Yoshida, Masahiro ;

Oga, Toru ;

Tomita, Yasuhiro ;

Hamada, Satoshi ;

Murase, Kimihiko ;

Mori, Hiroyuki ;

Wada, Hiroo ;

Uchiyama, Makoto ;

Ogawa, Hiromasa ;

Sato, Kazumichi ;

Nakata, Seiichi ;

Mishima, Kazuo ;

Momomura, Shin-Ichi .

RESPIRATORY INVESTIGATION, 2022, 60 (01) :3-32

[3] Influence of exogenous insulin on C-peptide levels in subjects with type 2 diabetes [J].

Albareda, M ;

Rigla, M ;

Rodríguez-Espinosa, J ;

Caballero, A ;

Chico, A ;

Cabezas, R ;

Carreras, G ;

Pérez, A .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2005, 68 (03) :202-206

[4]

[Anonymous], 1999, National baseline survey on prevalence and aetiology of anemia in Zambia: A random cluster community survey involving children, women and men

[5]

Araki E, 2020, DIABETOL INT, V11, P165, DOI [10.1111/jdi.13306, 10.1007/s13340-020-00439-5]

[6] Outcomes of bariatric surgery in geriatric patients ≥ 65 years: single institution study [J].