Leucine-rich Alpha-2 glycoprotein could be clinically useful in active and postoperative Crohn's disease

被引：0

作者：

Tashiro, Taku ^{[1
]}

Shinzaki, Shinichiro ^{[1
,2
]}

Yoshihara, Takeo ^{[1
]}

Tsujii, Yuri ^{[1
]}

Asakura, Akiko ^{[1
]}

Amano, Takahiro ^{[1
]}

Tani, Mizuki ^{[1
]}

Otake-Kasamoto, Yuriko ^{[1
]}

Uema, Ryotaro ^{[1
]}

Tsujii, Yoshiki ^{[1
]}

Inoue, Takahiro ^{[1
]}

Ogino, Takayuki ^{[3
]}

Iijima, Hideki ^{[1
,4
]}

Hayashi, Yoshito ^{[1
]}

Takehara, Tetsuo ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Hyogo Med Univ, Dept Gastroenterol, Fac Med, Nishinomiya, Japan

[3] Osaka Univ, Grad Sch Med, Dept Gastroenterol Surg, Suita, Osaka, Japan

[4] Osaka Keisatsu Hosp, Dept Internal Med, Osaka, Japan

来源：

SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期

关键词：

C-REACTIVE PROTEIN; CAPSULE ENDOSCOPY; BIOMARKER; SURGERY;

D O I：

10.1038/s41598-025-93831-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The clinical usefulness of serum leucine-rich alpha-2 glycoprotein (LRG) levels as a surrogate marker of endoscopic activity including postoperative recurrence in patients with Crohn's disease (CD) remains unclear, and LRG production in the small intestinal mucosa has not been explored. The present study investigated the usefulness of serum LRG to ascertain endoscopic activity, the secretion of LRG from the small intestinal mucosa, and the significance of LRG as a predictor of postoperative disease course. We included 364 patients who underwent transanal endoscopy at Osaka University Hospital. Serum LRG correlated highly with endoscopic severity (LRG, r = 0.65; CRP, r = 0.37) and reflected strictly moderate endoscopic activity better than serum CRP. Especially, serum LRG reflected mucosal healing even in patients whose inflammation was confined to the small intestine. In multivariate analyses, serum LRG was an independent factor influencing mucosal healing. LRG was more strongly expressed in the inflamed mucosa of the small intestine compared with that in uninflamed mucosa, and serum LRG was more strongly correlated with postoperative small intestinal recurrence severity than CRP (LRG, r = 0.62; CRP, r = 0.32). In conclusion, serum LRG is a useful surrogate marker of endoscopic CD severity and activity, with increased LRG expression in the small bowel predicting postoperative recurrence.

引用

页数：10

共 33 条

[1] Turner D., Et al., STRIDE-II: an update on the selecting therapeutic targets in inflammatory bowel disease (STRIDE) initiative of the international organization for the study of IBD (IOIBD): determining therapeutic goals for Treat-to-Target strategies in IBD, Gastroenterology, 160, pp. 1570-1583, (2021)
[2] Laterza L., Et al., Multiparametric evaluation predicts different Mid-Term outcomes in Crohn’s disease, Dig. Dis, 36, pp. 184-193, (2018)
[3] Bernstein C.N., Loftus E.V., Ng S.C., Lakatos P.L., Moum B., Hospitalisations and surgery in Crohn’s disease, Gut, 61, pp. 622-629, (2012)
[4] Ungaro R.C., Et al., Deep remission at 1 year prevents progression of early Crohn’s disease, Gastroenterology, 159, pp. 139-147, (2020)
[5] Neurath M.F., Travis S.P., Mucosal healing in inflammatory bowel diseases: a systematic review, Gut, 61, pp. 1619-1635, (2012)
[6] Serada S., Et al., iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases, Ann. Rheum. Dis, 69, pp. 770-774, (2010)
[7] Pepys M.B., Hirschfield G.M., C-reactive protein: a critical update, J. Clin. Invest, 111, pp. 1805-1812, (2003)
[8] Solem C.A., Et al., Correlation of C-reactive protein with clinical, endoscopic, histologic, and radiographic activity in inflammatory bowel disease, Inflamm. Bowel Dis, 11, pp. 707-712, (2005)
[9] Shinzaki S., Et al., Leucine-rich Alpha-2 glycoprotein is a serum biomarker of mucosal healing in ulcerative colitis, J. Crohns Colitis, 11, pp. 84-91, (2017)
[10] Kawamura T., Et al., Accuracy of serum Leucine-Rich Alpha-2 glycoprotein in evaluating endoscopic disease activity in Crohn’s disease, Inflamm. Bowel Dis, (2022)

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