ASCO highlights: neoadjuvant immunotherapy in mismatch repair deficient colorectal cancer

被引：1
作者：
Piringer, Gudrun [1 ]
机构：
[1] Johannes Kepler Univ Linz, Kepler Univ Hosp, Med Fac, Dept Hematol & Oncol, Linz, Austria
来源：
MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY | 2025年 / 18卷 / 01期
关键词：
Localized colorectal neoplasms; Organ preservation; Dostarlimab; Combined immunotherapy; Tumor mutation burden; CHEMOTHERAPY; DURATION;
D O I：
10.1007/s12254-024-01015-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite recent advances in therapy, certain subtypes of colorectal cancer, such as those that are microsatellite instability (MSI-high), mismatch repair deficient (dMMR) or tumor mutation burden high (TMB-H), remain a treatment challenge. In recent years, interest in neoadjuvant therapy strategies for localized colorectal cancer has increased-especially treatment with immunotherapies. At ASCO meeting 2024, updated data on 6-month course of dostarlimab in patients with dMMR locally advanced rectal cancer as well as several trials investigating the use of neoadjuvant immunotherapy monotherapy or immunotherapy combinations in high-risk stage II-III dMMR colon cancer were presented.
引用
收藏
页码：26 / 29
页数：4
相关论文
共 14 条
  • [1] Durable complete responses to PD-1 blockade alone in mismatch repair deficient locally advanced rectal cancer.
    Cercek, Andrea
    Sinopoli, Jenna Cohen
    Shia, Jinru
    Weiss, Jill A.
    Temple, Lindsay
    Smith, Jesse Joshua
    Saltz, Leonard B.
    Widmar, Maria
    Fumo, Gerard
    Aparo, Santiago
    Romesser, Paul Bernard
    Walch, Henry S.
    Patel, Mitesh
    Jayaprakasam, Vetri Sudar
    Kim, Tae-Hyung
    Paty, Philip
    Gonen, Mithat
    Garcia-Aguilar, Julio
    Weiser, Martin R.
    Diaz Jr, Luis A.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (17_SUPPL) : LBA3512 - LBA3512
  • [2] Neoadjuvant Treatment of Mismatch Repair-Deficient Colon Cancer - Clinically Meaningful?
    Cercek, Andrea
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2024, 390 (21) : 2024 - 2025
  • [3] PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer
    Cercek, Andrea
    Lumish, Melissa
    Sinopoli, Jenna
    Weiss, Jill
    Shia, Jinru
    Lamendola-Essel, Michelle
    El Dika, Imane H.
    Segal, Neil
    Shcherba, Marina
    Sugarman, Ryan
    Stadler, Zsofia
    Yaeger, Rona
    Smith, J. Joshua
    Rousseau, Benoit
    Argiles, Guillem
    Patel, Miteshkumar
    Desai, Avni
    Saltz, Leonard B.
    Widmar, Maria
    Iyer, Krishna
    Zhang, Janie
    Gianino, Nicole
    Crane, Christopher
    Romesser, Paul B.
    Pappou, Emmanouil P.
    Paty, Philip
    Garcia-Aguilar, Julio
    Gonen, Mithat
    Gollub, Marc
    Weiser, Martin R.
    Schalper, Kurt A.
    Diaz, Luis A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (25) : 2363 - 2376
  • [4] Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair-Deficient Colon Cancer
    Chalabi, Myriam
    Verschoor, Yara L.
    Tan, Pedro Batista
    Balduzzi, Sara
    Van Lent, Anja U.
    Grootscholten, Cecile
    Dokter, Simone
    Bueller, Nike V.
    Grotenhuis, Brechtje A.
    Kuhlmann, Koert
    Burger, Jacobus W.
    Huibregtse, Inge L.
    Aukema, Tjeerd S.
    Hendriks, Eduard R.
    Oosterling, Steven J.
    Snaebjornsson, Petur
    Voest, Emile E.
    Wessels, Lodewyk F.
    Beets-Tan, Regina G.
    Van Leerdam, Monique E.
    Schumacher, Ton N.
    van den Berg, Jose G.
    Beets, Geerard L.
    Haanen, John B.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2024, 390 (21) : 1949 - 1958
  • [5] Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers
    Chalabi, Myriam
    Fanchi, Lorenzo F.
    Dijkstra, Krijn K.
    Van den Berg, Jose G.
    Aalbers, Arend G.
    Sikorska, Karolina
    Lopez-Yurda, Marta
    Grootscholten, Cecile
    Beets, Geerard L.
    Snaebjornsson, Petur
    Maas, Monique
    Mertz, Marjolijn
    Veninga, Vivien
    Bounova, Gergana
    Broeks, Annegien
    Beets-Tan, Regina G.
    de Wijkerslooth, Thomas R.
    van Lent, Anja U.
    Marsman, Hendrik A.
    Nuijten, Elvira
    Kok, Niels F.
    Kuiper, Maria
    Verbeek, Wieke H.
    Kok, Marleen
    Van Leerdam, Monique E.
    Schumacher, Ton N.
    Voest, Emile E.
    Haanen, John B.
    [J]. NATURE MEDICINE, 2020, 26 (04) : 566 - +
  • [6] Ding KF., 2024, PREOPERATIVE NEOADJU, V3599
  • [7] Duration of Adjuvant Chemotherapy for Stage III Colon Cancer
    Grothey, A.
    Sobrero, A. F.
    Shields, A. F.
    Yoshino, T.
    Paul, J.
    Taieb, J.
    Souglakos, J.
    Shi, Q.
    Kerr, R.
    Labianca, R.
    Meyerhardt, J. A.
    Vernerey, D.
    Yamanaka, T.
    Boukovinas, I.
    Meyers, J. P.
    Renfro, L. A.
    Niedzwiecki, D.
    Watanabe, T.
    Torri, V.
    Saunders, M.
    Sargent, D. J.
    Andre, T.
    Iveson, T.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (13) : 1177 - 1188
  • [8] Neoadjuvant PD-1 blockade with toripalimab, with or without celecoxib, in mismatch repair-deficient or microsatellite instability-high, locally advanced, colorectal cancer (P1CC): a single-centre, parallel-group, noncomparative, randomised, phase 2 trial
    Hu, Huabin
    Kang, Liang
    Zhang, Jianwei
    Wu, Zehua
    Wang, Hui
    Huang, Meijin
    Lan, Ping
    Wu, Xiaojian
    Wang, Chao
    Cao, Wuteng
    Hu, Jiancong
    Huang, Yan
    Huang, Liang
    Wang, Huaiming
    Shi, Lishuo
    Cai, Yue
    Shen, Cailu
    Ling, Jiayu
    Xie, Xiaoyu
    Cai, Yonghua
    He, Xiaowen
    Dou, Ruoxu
    Zhou, Jiaming
    Ma, Tenghui
    Zhang, Xingwei
    Luo, Shuangling
    Deng, Weihao
    Ling, Li
    Liu, Hao
    Deng, Yanhong
    [J]. LANCET GASTROENTEROLOGY & HEPATOLOGY, 2022, 7 (01): : 38 - 48
  • [9] Duration of Adjuvant Doublet Chemotherapy (3 or 6 months) in Patients With High-Risk Stage II Colorectal Cancer
    Iveson, Timothy J.
    Sobrero, Alberto F.
    Yoshino, Takayuki
    Souglakos, Ioannis
    Ou, Fang-Shu
    Meyers, Jeffrey P.
    Shi, Qian
    Grothey, Axel
    Saunders, Mark P.
    Labianca, Roberto
    Yamanaka, Takeharu
    Boukovinas, Ioannis
    Hollander, Niels H.
    Galli, Fabio
    Yamazaki, Kentaro
    Georgoulias, Vassilis
    Kerr, Rachel
    Oki, Eiji
    Lonardi, Sara
    Harkin, Andrea
    Rosati, Gerardo
    Paul, James
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (06) : 631 - +
  • [10] Neoadjuvant Pembrolizumab in Localized Microsatellite Instability High/Deficient Mismatch Repair Solid Tumors
    Ludford, Kaysia
    Ho, Won Jin
    Thomas, Jane V.
    Raghav, Kanwal P. S.
    Murphy, Mariela Blum
    Fleming, Nicole D.
    Lee, Michael S.
    Smaglo, Brandon G.
    You, Y. Nancy
    Tillman, Matthew M.
    Kamiya-Matsuoka, Carlos
    Thirumurthi, Selvi
    Messick, Craig
    Johnson, Benny
    Vilar, Eduardo
    Dasari, Arvind
    Shin, Sarah
    Hernandez, Alexei
    Yuan, Xuan
    Yang, Hongqui
    Foo, Wai Chin
    Qiao, Wei
    Maru, Dipen
    Kopetz, Scott
    Overman, Michael J.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (12) : 2181 - +
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