ASCO highlights: neoadjuvant immunotherapy in mismatch repair deficient colorectal cancer

被引：2

作者：

Piringer, Gudrun ^{[1
]}

机构：

[1] Johannes Kepler Univ Linz, Kepler Univ Hosp, Med Fac, Dept Hematol & Oncol, Linz, Austria

来源：

MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY | 2025年 / 18卷 / 01期

关键词：

Localized colorectal neoplasms; Organ preservation; Dostarlimab; Combined immunotherapy; Tumor mutation burden; CHEMOTHERAPY; DURATION;

D O I：

10.1007/s12254-024-01015-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite recent advances in therapy, certain subtypes of colorectal cancer, such as those that are microsatellite instability (MSI-high), mismatch repair deficient (dMMR) or tumor mutation burden high (TMB-H), remain a treatment challenge. In recent years, interest in neoadjuvant therapy strategies for localized colorectal cancer has increased-especially treatment with immunotherapies. At ASCO meeting 2024, updated data on 6-month course of dostarlimab in patients with dMMR locally advanced rectal cancer as well as several trials investigating the use of neoadjuvant immunotherapy monotherapy or immunotherapy combinations in high-risk stage II-III dMMR colon cancer were presented.

引用

页码：26 / 29

页数：4

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