Causal associations between posttraumatic stress disorder and type 2 diabetes

被引：0

作者：

Song, Yuqing ^{[1
,2
]}

Baranova, Ancha ^{[3
,4
]}

Cao, Hongbao ^{[3
]}

Yue, Weihua ^{[1
,2
,5
,6
]}

Zhang, Fuquan ^{[7
,8
]}

机构：

[1] Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing 100191, Peoples R China

[2] Peking Univ, Peking Univ Hosp 6, Natl Clin Res Ctr Mental Disorders, NHC Key Lab Mental Hlth, Beijing 100191, Peoples R China

[3] George Mason Univ, Sch Syst Biol, Manassas, VA 20110 USA

[4] Res Ctr Med Genet, Moscow 115478, Russia

[5] Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China

[6] Chinese Inst Brain Res, Beijing 102206, Peoples R China

[7] Nanjing Med Univ, Affiliated Brain Hosp, Inst Neuropsychiat, Nanjing 210029, Peoples R China

[8] Nanjing Med Univ, Dept Psychiat, Affiliated Brain Hosp, 264 Guangzhou Rd, Nanjing 210029, Peoples R China

来源：

DIABETOLOGY & METABOLIC SYNDROME | 2025年 / 17卷 / 01期

关键词：

Posttraumatic stress disorder; Diabetes; Mendelian randomization; EARTHQUAKE SURVIVORS; METABOLIC SYNDROME; HORMONE-LEVELS; PTSD;

D O I：

10.1186/s13098-025-01630-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Posttraumatic stress disorder (PTSD) patients have a high comorbidity with type 2 diabetes (T2D). Whether PTSD influences the risk of diabetes is still not known. We used GWAS data from European ancestry of PTSD (23,121 cases and 151,447 controls) and T2D (80,154 cases and 853,816 controls) to investigate the bidirectional associations between PTSD and T2D by the Mendelian randomization (MR) analysis. We showed that PTSD was causally associated with higher odds of T2D (OR = 1.04, 95% CI: 1.01-1.06, P = 0.0086), but not vice versa. Our study suggests that PTSD may increase the risk of T2D. PTSD sufferers should be screened for T2D and its precursor known as metabolic syndrome.

引用

页数：5

共 35 条

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