Prevalence and associated factors with low birth weight among human immunodeficiency virus exposed infants between 2004 and 2021 in Hubei, China: a retrospective cohort study

被引:0
作者
Liu, Jinli [1 ,2 ]
Wu, Songjie [3 ]
Zou, Shi [1 ]
Yan, Yajun [1 ]
Feng, Ling [1 ]
Guo, Wei [4 ,5 ]
Wu, Mengmeng [1 ,2 ]
Tang, Weiming [6 ,7 ]
Liang, Ke [1 ,2 ,3 ,8 ]
机构
[1] Wuhan Univ, Dept Infect Dis, Zhongnan Hosp, Wuhan, Peoples R China
[2] Chinese Acad Med Sci, Wuhan Res Ctr Infect Dis & Canc, Wuhan, Peoples R China
[3] Wuhan Univ, Dept Nosocomial Infect Management, Zhongnan Hosp, Wuhan, Peoples R China
[4] Wuhan Univ, Zhongnan Hosp, Dept Pathol, Wuhan, Peoples R China
[5] Wuhan Univ, Sch Basic Med Sci, Dept Pathol, Wuhan, Peoples R China
[6] Prov Peoples Hosp, Guangzhou, Peoples R China
[7] Univ North Carolina Chapel Hill Project China, Guangzhou, Peoples R China
[8] Hubei Engn Ctr Infect Dis Prevent, Control & Treatment, Wuhan, Peoples R China
关键词
Low birth weight; HIV-exposed infants; Antiretroviral therapy; Protease inhibitor; TO-CHILD TRANSMISSION; ANTIRETROVIRAL THERAPY; HIV-INFECTION; PREGNANCY; OUTCOMES; IMPACT; WOMEN; ERA;
D O I
10.1186/s12889-025-21707-6
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background Low birth weight (LBW, < 2500 g) is an essential indicator of neonatal death and poor infant development, but data on LBW among human immunodeficiency virus (HIV)-exposed infants in China is inadequate. Objective This study aimed to explore the temporal trend and factors associated with the LBW among HIV-exposed infants in Hubei province, China. Methods The pregnant women living with HIV in Hubei province, China between Jan 2004 and Dec 2021 were enrolled this study. Recruited HIV-positive women were provided with consultation about preventing mother-to-child transmission (PMTCT). The intervention measures for PMTCT were provided to pregnant women and HIV-exposed infants, and the LBW and HIV status of infants were followed. Collected data included women's demographic information, HIV status of sexual partner, route of HIV transmission, HBV infection, HCV infection, syphilis infection, intrapartum CD4 count, whether received antiretroviral therapy (ART), the time of ART initiation, and ART regimens during pregnancy. Multivariable logistic regression was used to analyze factors associated with the LBW. Results In total, 531 mothers (581 pregnancy events) and 581 infants were enrolled. The mean birth weight and LBW rate were 3075 +/- 470.2 g and 8.4%, respectively. From 2004 to 2021, a significantly increased LBW rate (4.7-14.0%, P = .004) was observed. The use of protease inhibitor (PI)-based regimen (P = .04) and the exposure to ART in the first trimester (P = .01) were positively correlated with the increase of LBW rate. Exposure to ART in the first trimester (adjusted odds ratio [aOR] 3.64, 95%CI 1.29-10.27) and the second trimester (aOR 4.53, 95%CI 1.52-13.48), premature delivery (aOR 48.44, 95%CI 16.98-138.18), and infant with HIV infection (aOR 5.91, 95%CI 1.55-22.58) were predictors for LBW. Conclusions The significantly increased LBW rate in our study indicated that specific attention should be paid to HIV-exposed infants in China. More importantly, our study identified significant factors that can predict the risk of LBW. Interventions targeting these risk factors may prevent LBW among pregnant women living with HIV in future research and prenatal care.
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页数:10
相关论文
共 43 条
[1]   Impact of children born with low birth weight on stunting and wasting in Sindh province of Pakistan: a propensity score matching approach [J].
Abbas, Faisal ;
Kumar, Ramesh ;
Mahmood, Tahir ;
Somrongthong, Ratana .
SCIENTIFIC REPORTS, 2021, 11 (01)
[2]   Dolutegravir versus ritonavir-boosted lopinavir both with dual nucleoside reverse transcriptase inhibitor therapy in adults with HIV-1 infection in whom first-line therapy has failed (DAWNING): an open-label, non-inferiority, phase 3b trial [J].
Aboud, Michael ;
Kaplan, Richard ;
Lombaard, Johannes ;
Zhang, Fujie ;
Hidalgo, Jose A. ;
Mamedova, Elmira ;
Losso, Marcelo H. ;
Chetchotisakd, Ploenchan ;
Brites, Carlos ;
Sievers, Jorg ;
Brown, Dannae ;
Hopking, Judy ;
Underwood, Mark ;
Nascimento, Maria Claudia ;
Punekar, Yogesh ;
Gartland, Martin ;
Smith, Kimberly .
LANCET INFECTIOUS DISEASES, 2019, 19 (03) :253-264
[3]  
AIDS and Hepatitis C Professional Group Society of Infectious Diseases Chinese Medical Association, 2021, Zhonghua Nei Ke Za Zhi, V60, P1106, DOI 10.3760/cma.j.cn112138-20211006-00676
[4]  
[Anonymous], 2010, Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: Recommendations for a public health approach
[5]  
[Anonymous], 2016, Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection, DOI 10.1016/j.jped.2014.04.007
[6]   Contribution of Maternal Antiretroviral Therapy and Breastfeeding to 24-Month Survival in Human Immunodeficiency Virus-Exposed Uninfected Children: An Individual Pooled Analysis of African and Asian Studies [J].
Arikawa, Shino ;
Rollins, Nigel ;
Jourdain, Gonzague ;
Humphrey, Jean ;
Kounis, Athena P. ;
Hoffman, Irving ;
Essex, Max ;
Farley, Tim ;
Coovadia, Hoosen M. ;
Gray, Glenda ;
Kuhn, Louise ;
Shapiro, Roger ;
Leroy, Valerian ;
Bollinger, Robert C. ;
Onyango-Makumbi, Carolyne ;
Lockman, Shahin ;
Marquez, Carina ;
Doherty, Tanya ;
Dabis, Francois ;
Mandelbrot, Laurent ;
Le Coeur, Sophie ;
Rolland, Matthieu ;
Joly, Pierre ;
Newell, Marie-Louise ;
Becquet, Renaud .
CLINICAL INFECTIOUS DISEASES, 2018, 66 (11) :1668-1677
[7]   HIV treatment in pregnancy [J].
Bailey, Heather ;
Zash, Rebecca ;
Rasi, Virginia ;
Thorne, Claire .
LANCET HIV, 2018, 5 (08) :E457-E467
[8]   Pathophysiology of placental-derived fetal growth restriction [J].
Burton, Graham J. ;
Jauniaux, Eric .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2018, 218 (02) :S745-S761
[9]   Antiretroviral Drug Regimens to Prevent Mother-To-Child Transmission of HIV: A Review of Scientific, Program, and Policy Advances for Sub-Saharan Africa [J].
Chi, Benjamin H. ;
Stringer, Jeffrey S. A. ;
Moodley, Dhayendre .
CURRENT HIV/AIDS REPORTS, 2013, 10 (02) :124-133
[10]  
China, 2017, Implementation plan for prevention of mother-to-child transmission of HIV, syphilis, and hepatitis B