The Comparison between Pilot-Grade Spray Dryer and Laboratory-Grade Spray Dryer: Structure, Powder Properties and Application for Direct Compaction

被引：2

作者：

Li, Zhe ^{[1
]}

Peng, Wanghai ^{[1
]}

Chen, Fucai ^{[1
]}

Zhu, Lin ^{[1
,3
]}

Naeem, Abid ^{[1
,2
]}

Zhu, Weifeng ^{[1
]}

Guan, Yongmei ^{[1
]}

Feng, Yi ^{[1
,4
]}

Wu, Yanni ^{[5
]}

Lin, Xiao ^{[1
,4
]}

Ming, Liangshan ^{[1
]}

机构：

[1] Jiangxi Univ Chinese Med, Inst Adv Study, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China

[2] Beijing Inst Technol, Key Lab Mol Med & Biotherapy, Key Lab Med Mol Sci & Pharmaceut Engn, Adv Res Inst Multidisciplinary Sci,Sch Life Sci,Co, Beijing 100081, Peoples R China

[3] Univ Macau, Inst Chinese Med Sci, Macau Ctr Res & Dev Chinese Med, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[4] Shanghai Univ Tradit Chinese Med, Engn Res Ctr Modern Preparat Technol TCM, Minist Educ, Shanghai 201203, Peoples R China

[5] Jiangzhong Pharmaceut Co Ltd, Nanchang 330049, Peoples R China

来源：

AAPS PHARMSCITECH | 2024年 / 25卷 / 08期

关键词：

direct compaction; flowability; particle design; spray drying; tabletability; CO-PROCESSED EXCIPIENT; DRYING FORMULATION; TABLETS; FUNCTIONALITY; PARAMETERS; PLATFORM; RELEASE;

D O I：

10.1208/s12249-024-02991-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study investigates the improvements in direct compaction powder properties achieved through particle design using laboratory and pilot-scale spray dryers. Hydroxypropyl methylcellulose and polyvinylpyrrolidone were used as modifying agent, which have low hygroscopicity and surface tension, good flowability, and excellent compactibility. Ammonium bicarbonate and sodium bicarbonate were used as pore-forming agents, and the composite particles were prepared using laboratory and pilot-scale spray dryers. The results showed that the structure of the composite particles and porous particles can effectively improve the flowability, tabletability, and disintegration behaviour; the composite particles prepared by laboratory-scale spray drying have better tabletability; the composite particles prepared by spray drying at pilot-scale had better flowability. In summary, there are significant differences in the properties of products prepared by different scales of spray drying. It will be beneficial to choose the appropriate equipment and the appropriate experimental design. Consequently, this study may contribute to the development of natural plant tablets.

引用

页数：20

共 51 条

[21] Achieving a robust drug release from extended release tablets using an integrated continuous mixing and direct compression line [J].