BCMA-targeted therapies for multiple myeloma: latest updates from 2024 ASH annual meeting

被引:3
作者
Zheng, Huijian [1 ]
Xian, Huajian [2 ]
Zhang, Wenjie [1 ]
Lu, Chaoqun [2 ]
Pan, Renyao [1 ]
Liu, Han [2 ]
Xu, Zhenshu [1 ]
机构
[1] Fujian Med Univ, Union Hosp, Fujian Inst Hematol, Fujian Prov Key Lab Hematol, 29 Xinquan Rd, Fuzhou 350001, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Natl Res Ctr Translat Med Shanghai, Shanghai Inst Hematol,State Key Lab Med Genom,Sch, Shanghai 200025, Peoples R China
基金
中国国家自然科学基金;
关键词
BCMA-targeted therapies; Multiple myeloma; ASH; 2024;
D O I
10.1186/s13045-025-01675-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B-cell maturation antigen (BCMA) is currently the most extensively explored target for multiple myeloma (MM). BCMA-targeted therapies such as antibody-drug conjugate (ADC), bispecific antibodies (BsAbs), chimeric antigen receptor T(CAR-T) cell have shown promising therapeutic prospects in MM. We have summarized the latest reports on the three types of drugs for MM at the 2024 ASH Annual Meeting.
引用
收藏
页数:4
相关论文
共 11 条
[1]   Belantamab Mafodotin Plus Pomalidomide and Dexamethasone Vs Pomalidomide Plus Bortezomib and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma: A Subset Analysis in Patients Who Have Received 1 Prior Line of Therapy Including Lenalidomide [J].
Beksac, Meral ;
Garcia, Esther Gonzalez ;
Delimpasi, Sosana ;
Robak, Pawel ;
Karunanithi, Kamaraj ;
De Arriba, Felipe ;
Radocha, Jakub ;
Kim, Kihyun ;
Voloshin, Sergey ;
Zherebtsova, Vera ;
Osipov, Iurii ;
Mateos, Maria-Victoria ;
Zafar, Syed F. ;
Pour, Ludek ;
Spicka, Ivan ;
Suzuki, Kazuhito ;
Du, Xin ;
Wilkes, Jodie ;
Maroj, Brijesh ;
Morris, Kristin ;
Ma, Jie ;
Polinkovsky, Margaret ;
Wang, Zhaohui ;
Zhou, Xiaoou L. ;
Fulci, Giulia ;
Sule, Neal ;
Kremer, Brandon ;
Opalinska, Joanna ;
Trudel, Suzanne ;
Dimopoulos, Meletios A. .
BLOOD, 2024, 144 :4731-4733
[2]  
Bishop MR, 2024, Blood, V144, P4825
[3]   Teclistamab, Daratumumab, and Pomalidomide in Patients with Relapsed/Refractory Multiple Myeloma: Results from the Majestec-2 Cohort a and Trimm-2 Studies [J].
D'Souza, Anita ;
Costa, Luciano J. ;
San-Miguel, Jesus F. ;
Berdeja, Jesus G. ;
Giles, Daniel Morillo ;
Touzeau, Cyrille ;
Mckay, John ;
Dholaria, Bhagirathbhai ;
Martin, Thomas G. ;
Perrot, Aurore ;
Oriol, Albert ;
Balari, Anna Sureda ;
Prior, Thomas ;
Ghosh, Debopriya ;
Kang, Lijuan ;
Larsen, Julie S. ;
Ludlage, Hein ;
Vandenberk, Lien ;
Chen, Lingling ;
Koster, Bas ;
Sun, Weili ;
Kobos, Rachel ;
Searle, Emma ;
Matous, Jeffrey, V ;
Chari, Ajai ;
Kampfenkel, Tobias .
BLOOD, 2024, 144 :498-498
[4]   Phase 2 Registrational Study of Anitocabtagene Autoleucel for the Treatment of Patients with Relapsed and/or Refractory Multiple Myeloma: Preliminary Results from the IMMagine-1 Trial [J].
Freeman, Ciara Louise ;
Dhakal, Binod ;
Kaur, Gurbakhash ;
Maziarz, Richard T. ;
Callander, Natalie ;
Sperling, Adam S. ;
Schinke, Carolina ;
Jakubowiak, Andrzej J. ;
Biran, Noa ;
Sborov, Douglas W. ;
Varga, Cindy ;
Deol, Abhinav ;
Kanate, Abraham S. ;
Kocoglu, Mehmet Hakan ;
Solh, Melhem M. ;
Banerjee, Kamalika ;
Chan, Rebecca ;
Nahas, Myrna ;
Kostic, Ana ;
Granados, Enrique ;
Jackson, Carolyn ;
Heery, Christopher R. ;
Welliver, Tim ;
Patel, Krina K. ;
Frigault, Matthew .
BLOOD, 2024, 144 :1031-1033
[5]  
Hungria V., 2024, Blood, V144, P10
[6]   Belantamab Mafodotin, Bortezomib, and Dexamethasone Vs Daratumumab, Bortezomib, and Dexamethasone in Relapsed/Refractory Multiple Myeloma: Overall Survival Analysis and Updated Efficacy Outcomes of the Phase 3 Dreamm-7 Trial [J].
Hungria, Vania ;
Robak, Pawel ;
Hus, Marek ;
Zherebtsova, Vera ;
Ward, Christopher ;
Ho, Phoebe Joy ;
Hajek, Roman ;
Kim, Kihyun ;
Grosicki, Sebastian ;
Sia, Hanlon ;
Bryant, Adam ;
Lacerda, Marcelo Pitombeira de ;
Martinez, Gracia Aparecida ;
Balari, Anna Maria Sureda ;
Sandhu, Irwindeep ;
Cerchione, Claudio ;
Ganly, Peter ;
Dimopoulos, Meletios ;
Fu, Chengcheng ;
Garg, Mamta ;
Abdallah, Al-Ola ;
Gatt, Moshe E. ;
Oriol, Albert ;
Cavo, Michele ;
Rifkin, Robert ;
Fujisaki, Tomoaki ;
Mielnik, Micha ;
Pirooz, Nick ;
Lee, Joe ;
Mckeown, Astrid ;
Rogers, Rachel ;
Baig, Hena ;
Eccersley, Lydia ;
Roy-Ghanta, Sumita ;
Mateos, Maria Victoria .
BLOOD, 2024, 144 :772-774
[7]  
Popat R, 2024, Blood, V144, P1032, DOI [10.1182/blood, DOI 10.1182/BLOOD]
[8]   Phase 2 Study of Teclistamab-Based Induction Regimens in Patients with Transplant-Eligible (TE) Newly Diagnosed Multiple Myeloma (NDMM): Results from the GMMG-HD10/DSMM-(( (MajesTEC-5) Trial [J].
Raab, Marc S. ;
Weinhold, Niels ;
Kortuem, K. Martin ;
Kroenke, Jan ;
Podola, Lilli ;
Bertsch, Uta ;
Frenking, Jan H. ;
Mersi, Julia ;
Huhn, Stefanie ;
Hundemer, Michael ;
Mechtersheimer, Gunhild ;
Fenk, Roland ;
Weisel, Katja C. ;
Schub, Natalie ;
Bassermann, Florian ;
Engelhardt, Monika ;
Teipel, Raphael ;
Hanel, Mathias ;
Salwender, Hans ;
Koster, Bas ;
Ershova, Elena ;
Sakabedoyan, Caline ;
Barrott, Isobel ;
Balogh, Agnes ;
Vara, Sanjay ;
Kampfenkel, Tobias ;
Goldschmidt, Hartmut ;
Einsele, Hermann ;
Rasche, Leo .
BLOOD, 2024, 144 :493-495
[9]  
Usmani SZ., 2024, Updated Interim Anal Blood, V144, P497
[10]   BCMA-targeted immunotherapy for multiple myeloma [J].
Yu, Bo ;
Jiang, Tianbo ;
Liu, Delong .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2020, 13 (01)