Predictive value of preoperative systemic immune-inflammation index and prognostic nutrition index in patients with epithelial ovarian cancer

被引:3
作者
Chen, Jingping [1 ,2 ]
Jin, Lu [2 ]
Luo, Rui [1 ]
Zhang, Xiaofei [1 ]
Chen, Yizhi [1 ,3 ]
Han, Ze [1 ,2 ]
Liu, Tianfeng [1 ,2 ,3 ]
机构
[1] Linyi Peoples Hosp, Dept Gynecol, Linyi 276000, Shandong, Peoples R China
[2] Binzhou Med Coll, Binzhou 256600, Shandong, Peoples R China
[3] Jinzhou Med Univ, Jinzhou 121000, Liaoning, Peoples R China
关键词
Epithelial ovarian cancer; Prognostic nutrition index; Systemic immune-inflammation index; Overall survival; Prognosis; TUMOR; SURVIVAL; RATIO;
D O I
10.1186/s13048-025-01631-4
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background This study aimed to evaluate the predictive value of Prognostic Nutritional Index (PNI), Systemic Immunoinflammatory Index (SII), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) in patients with epithelial ovarian cancer ( EOC). Also, to explore the predictive value of a new scoring system combining PNI and SII (coPNI-SII) in patients with EOC. Methods In this study, 154 patients with EOC were analyzed and classified according to the best cut-off values for SII, PNI, PLR, and NLR. Spearman's rank correlation was used to analyze the correlation of variables. The Kaplan-Meier survival curve and log-rank test were used to investigate the relationship between inflammatory indicators and overall survival (OS), which was then followed by a multivariate Cox proportional hazards model. All patients were categorized into three groups based on PNI-SII scores. The coPNI-SII score ranged from 1 to 3 as follows: score of 1, high PNI (>= 48.98) and low SII(< 998.87); score of 2, high PNI and high SII or low PNI and low SII; score of 3, low PNI and high SII. To assess the prognostic value of coPNI-SII in patients with EOC. Results The areas under the ROC curves for SII, PNI, PLR, NLR, and coPNI-SII were 0.814, 0.814, 0.780, 0.769, and 0.860, respectively. The optimal cut-off values for SII, PNI, PLR, and NLR were 998.87, 48.98, 217.63, and 2.61, respectively. The Kaplan-Meier analysis showed that the OS of the patients in the high PNI group, low SII group, low NLR group, and low PLR group was significantly higher than that of the patients in the low PNI group, high SII group,high NLR group, and high PLR group (p < 0.01). SII (P = 0.034), PNI (P = 0.013), FIGO staging (P = 0.009), ascites (P = 0.003), CA199 (P = 0.003), HE4 (P = 0.028), residual lesions (P = 0.022), and margins of incision (P < 0.001) were found to be significant prognostic indicators of OS by multifactorial Cox regression analysis. There was a significant inverse relationship between the PNI and SII (r = -0.484; P < 0.01). EOC patients with a coPNI-SII score of 1 had a higher 5-year OS rate (P < 0.05) than EOC patients with a coPNI-SII score of 2 or 3. When taking into account both the SII and PNI, the predictive value rose. Conclusion Interestingly, we found that low preoperative PNI and high SII were strong indicators of poor prognosis in patients with EOC. The combination of SII and PNI can enhance the accuracy of prognosis.
引用
收藏
页数:14
相关论文
共 35 条
[1]   The Lymphocyte-to-Monocyte Ratio is a Superior Predictor of Overall Survival in Comparison to Established Biomarkers of Resectable Colorectal Cancer [J].
Chan, Joseph C. Y. ;
Chan, David L. ;
Diakos, Connie I. ;
Engel, Alexander ;
Pavlakis, Nick ;
Gill, Anthony ;
Clarke, Stephen J. .
ANNALS OF SURGERY, 2017, 265 (03) :539-546
[2]   Prognostic significance of preoperative prognostic nutritional index in ovarian cancer A systematic review and meta-analysis [J].
Dai, Yan ;
Liu, Mingbo ;
Lei, Li ;
Lu, Shentao .
MEDICINE, 2020, 99 (38) :E21840
[3]   Platelet Effects on Ovarian Cancer [J].
Davis, Ashley N. ;
Afshar-Kharghan, Vahid ;
Sood, Anil K. .
SEMINARS IN ONCOLOGY, 2014, 41 (03) :378-384
[4]   Relationship Between Lymphocytopenia and Circulating Tumor Cells as Prognostic Factors for Overall Survival in Metastatic Breast Cancer [J].
De Giorgi, Ugo ;
Mego, Michal ;
Scarpi, Emanuela ;
Giuliano, Mario ;
Giordano, Antonio ;
Reuben, James M. ;
Valero, Vicente ;
Ueno, Naoto T. ;
Hortobagyi, Gabriel N. ;
Cristofanilli, Massimo .
CLINICAL BREAST CANCER, 2012, 12 (04) :264-269
[5]   Inflammation and nutritional status indicators as prognostic indicators for patients with locally advanced gastrointestinal stromal tumors treated with neoadjuvant imatinib [J].
Ding, Ping'an ;
Wu, Jiaxiang ;
Wu, Haotian ;
Sun, Chenyu ;
Guo, Honghai ;
Lowe, Scott ;
Yang, Peigang ;
Tian, Yuan ;
Liu, Yang ;
Meng, Lingjiao ;
Zhao, Qun .
BMC GASTROENTEROLOGY, 2023, 23 (01)
[6]   Predictive Effect of Systemic Immune-Inflammation Index Combined With Prognostic Nutrition Index Score on Efficacy and Prognosis of Neoadjuvant Intraperitoneal and Systemic Paclitaxel Combined With Apatinib Conversion Therapy in Gastric Cancer Patients With Positive Peritoneal Lavage Cytology: A Prospective Study [J].
Ding, Ping'an ;
Yang, Peigang ;
Sun, Chenyu ;
Tian, Yuan ;
Guo, Honghai ;
Liu, Yang ;
Li, Yong ;
Zhao, Qun .
FRONTIERS IN ONCOLOGY, 2022, 11
[7]   Immune Therapy for Cancer [J].
Dougan, Michael ;
Dranoff, Glenn .
ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :83-117
[8]   Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative resection of gastric cancer [J].
Dutta, Sumanta ;
Crumley, Andrew B. C. ;
Fullarton, Grant M. ;
Horgan, Paul G. ;
McMillan, Donald C. .
AMERICAN JOURNAL OF SURGERY, 2012, 204 (03) :294-299
[9]   The preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancer [J].
Feng, Zheng ;
Wen, Hao ;
Ju, Xingzhu ;
Bi, Rui ;
Chen, Xiaojun ;
Yang, Wentao ;
Wu, Xiaohua .
BMC CANCER, 2018, 18
[10]   Angiogenesis inhibitors for the treatment of epithelial ovarian cancer [J].
Gaitskell, Kezia ;
Rogozinska, Ewelina ;
Platt, Sarah ;
Chen, Yifan ;
Abd El Aziz, Mohamed ;
Tattersall, Abigail ;
Morrison, Jo .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2023, (04)