Synthesis and Antiviral Activity of Mannich Bases of Dehydroquinopimaric Acid and Maleopimaric Acid Alkyl Derivatives

被引：0
作者：
Smirnova, A. A. [1 ]
Tretyakova, E. V. [1 ]
Zarubaev, V. V. [2 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, Ufa Fed Res Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia
[2] Pasteur St Petersburg Sci Res Inst Epidemiol & Mic, 14 Mira St, St Petersburg 197001, Russia
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2024年 / 60卷 / 06期
关键词：
quinopimaric acid; maleopimaric acid; Mannich reaction; antiviral activity;
D O I：
10.1007/s10600-024-04518-w
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New aminomethyl diterpenoids were synthesized by Cu(I)-catalyzed Mannich reactions of maleopimaric acid or 1a,4a-dehydroquinopimaric acid alkyl derivatives, amines, and paraformaldehyde. Studies of the antiviral activity of the synthesized compounds showed that C20-modified Mannich bases of the propargyl ester and propargylamide of maleopimaric acid had the highest activity against influenza A virus (H1N1) with therapeutic indices SI 31-49.
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页码：1051 / 1055
页数：5
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