Association of type 2 diabetes and osteoarthritis: an umbrella review of systematic reviews and meta-analyses

被引：0
作者：
Vaishya, Raju [1 ]
Misra, Anoop [2 ]
Patralekh, Mohit Kumar [3 ]
Kalra, Pulkit [1 ]
Vaish, Abhishek [1 ]
Migliorini, Filippo [4 ,5 ]
机构：
[1] Indraprastha Apollo Hosp, Dept Orthopaed, New Delhi 110076, India
[2] Fortis C Doc Hosp, Dept Diabet & Endocrinol, Nehru Pl, New Delhi, India
[3] Vardhman Med Coll & Safdarjung Hosp, Dept Orthopaed, Ring Rd, New Delhi, India
[4] Link Campus Univ, Dept Life Sci Hlth & Hlth Profess, Via Casale San Pio 5, I-00165 Rome, Italy
[5] Acad Hosp Bolzano SABES ASDAA, Dept Orthoped & Trauma Surg, I-39100 Bolzano, Italy
来源：
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY | 2025年 / 35卷 / 01期
关键词：
Type; 2; diabetes; Osteoarthritis; Body mass index; Obesity; RADIOGRAPHIC KNEE OSTEOARTHRITIS; METABOLIC SYNDROME; RISK-FACTORS; MELLITUS; POPULATION; PREVALENCE; OVERWEIGHT; HAND; HIP; OBESITY;
D O I：
10.1007/s00590-025-04231-6
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
IntroductionAn association between type 2 diabetes and osteoarthritis has been postulated. The present umbrella review of systematic reviews and meta-analyses investigated possible bidirectional relationships between type 2 diabetes and osteoarthritis.MethodsPubMed, Scopus, Web of Science, and Cochrane Library databases were accessed. All the available systematic reviews and meta-analyses on the relationship between type 2 diabetes and osteoarthritis were accessed. The odds ratio (OR) effect measure and 95% confidence interval (CI) were used for the statistical analyses.ResultsFour systematic reviews, of whom three meta-analyses, were considered. Data from 26209 patients with osteoarthritis were considered: 3530 with type 2 diabetes and 22679 without type 2 diabetes. A significantly increased rate of osteoarthritis was evidenced in patients with type 2 diabetes than in patients without it (OR = 1.43; 95% CI 1.01 to 2.02). The effect persisted after in the subgroups age, sex, and obesity (pooled adjusted OR = 1.22; 95% CI 1.05 to 1.42).ConclusionPatients with type 2 diabetes might present an increased risk of developing osteoarthritis.
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